| Type | Description |
|---|---|
| Definition | HGF-regulated tyrosine kinase substrate |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 12:20:00 | The knockdown of Syk and Hrs enhances TLR3-mediated antiviral response in the form of IFN-beta, IL-6, and CXCL8 secretion. | 31089414 |
| 2018-02-03 10:44:00 | Findings find that Hrs is indispensable for the autophagic clearance of neurodegeneration-related proteins and for the survival of hippocampal neurons in mammals. In particular, the work provides the novel insight that the loss of Hrs results in insufficient autophagic clearance and enhanced ER stress, thereby triggering JNK activation and subsequent apoptotic and necroptotic neuronal cell death. | 27112194 |
| 2016-05-07 11:35:00 | HGS expression in the nervous system is developmentally regulated.HGS is required for motor neuron function. | 26115514 |
| 2016-03-19 10:38:00 | Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility. | 26078721 |
| 2015-02-14 12:59:00 | ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. | 25296754 |
| Type | IDs |
|---|---|
| Synonymous | Hgr, Hrs, ZFYVE8, tn |
| Gene |
UniProtKB-ID:
HGS_MOUSE,
Q3UMA3_MOUSE
UniprotKB:
Q99LI8,
Q3UMA3
UniParc:
UPI0000028C90,
UPI00005AC398
EMBL:
D50050,
BC003239,
AK046299,
AL669855,
AK145031
Ensembl:
ENSMUSG00000025793
KO:
mmu:15239
|
| Nucleutide sequences |
EMBL-CDS:
BAC32676.1,
AAH03239.1,
BAA08768.1,
BAE26195.1
Ensembl_TRS:
ENSMUST00000106205,
ENSMUST00000106203
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000101811,
ENSMUSP00000101809
RefSeq:
XP_006532335.2,
XP_030101450.1,
XP_006532333.2,
XP_006532334.2,
NP_001152800.1,
NP_032270.3,
XP_006532337.2,
XP_006532336.2
|
| Others |
UniRef100:
UniRef100_Q99LI8,
UniRef100_Q3UMA3
UniRef90:
UniRef90_Q9JJ50,
UniRef90_Q99LI8
UniRef50:
UniRef50_Q9JJ50,
UniRef50_O14964
UniGene:
Mm.7919
CCDS:
CCDS88297.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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