| Type | Description |
|---|---|
| Definition | FYVE, RhoGEF and PH domain containing 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 11:25:00 | *FGD5 tyrosine phosphorylation is essential for endothelial junction stabilization. | 31267715 |
| 2019-09-14 10:21:00 | Human FYVE domain containing proteins, those within the faciogenital dysplasia (Fgd) subfamily are particularly divergent and couple with GTPases to exert unique cellular functions. | 30308128 |
| 2019-08-03 10:49:00 | The study demonstrated cytoplasmic and nuclear FGD5 staining in a large proportion of primary breast cancers and lymph node metastases. The proportion of FGD5-positive lymph nodes was higher compared with the corresponding primary tumors. There was an association between FGD5 amplification status and nuclear FGD5 staining; however, neither proliferation nor prognosis was found to be associated with FGD5 expression. | 30052477 |
| 2018-06-16 12:02:00 | We found that depletion of FGD5 in microvascular cells inhibited their migration towards a stable VEGFA gradient. Furthermore, depletion of FGD5 resulted in accelerated VEGFR2 degradation, which was reverted by lactacystin-mediated proteasomal inhibition. Our results thus suggest a mechanism whereby FGD5 sustains VEGFA signaling and endothelial cell chemotaxis via inhibition of proteasome-dependent VEGFR2 degradation. | 28927665 |
| 2017-12-16 11:10:00 | FGD5 regulates VEGFR2 retention in recycling endosomes and coupling to PI3 (phosphoinositide-3) kinase/mTORC2-dependent cytoskeletal remodeling in endothelial cells. | 29051140 |
| Type | IDs |
|---|---|
| Synonymous | ZFYVE23 |
| Gene |
UniProtKB-ID:
FGD5_HUMAN,
A0A2X0SFF2_HUMAN,
B7ZM68_HUMAN
UniprotKB:
Q6ZNL6,
A0A2X0SFF2,
B7ZM68
UniParc:
UPI000189A843,
UPI00002372AE,
UPI0000074217
EMBL:
BF989107,
BX538312,
AC090954,
AK097276,
BX640820,
AC090937,
AK123054,
AK096856,
AC087591,
AK131078,
BC144300,
LS482385,
KF495759,
BC035364
Ensembl:
ENSG00000154783
KO:
hsa:152273
|
| Nucleutide sequences |
EMBL-CDS:
BAC04878.1,
CAE45896.2,
CAD98090.1,
BAG53865.1,
AAH35364.1,
BAC04989.1,
BAC85128.1,
SPT35762.1,
AAI44301.1
Ensembl_TRS:
ENST00000285046,
ENST00000543601
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000285046,
ENSP00000445949
RefSeq:
XP_011531724.1,
NP_689749.3,
XP_011531725.1,
NP_001307205.1
|
| Others |
UniRef100:
UniRef100_Q6ZNL6,
UniRef100_B7ZM68
UniRef90:
UniRef90_Q6ZNL6
UniRef50:
UniRef50_Q6ZNL6
UniGene:
Hs.412406
CCDS:
CCDS46767.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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