| Type | Description |
|---|---|
| Definition | forkhead box F1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 10:59:00 | FOXF1 mutations identified in 28 subjects with ACDMPV. Foxf1WT/S52F knock-in mice recapitulated histopathologic findings in ACDMPV infants. The S52F FOXF1 mutation disrupted protein-protein interactions and inhibited transcription of Stat3 signaling and endothelial proliferation were reduced in Foxf1WT/S52F mice and human ACDMPV lungs. | 31199666 |
| 2020-01-25 11:16:00 | Knockout of Foxf1 and Foxf2 together, but not alone, from mouse smooth muscle resulted in delayed liquid gastric emptying | 30565344 |
| 2019-09-21 11:36:00 | FOXF1 deletion increases myofibroblast invasion and collagen secretion and promotes a switch from N-cadherin (CDH2) to Cadherin-11 (CDH11), which is a critical step in the acquisition of the pro-fibrotic phenotype. FOXF1 directly binds to Cdh2 and Cdh11 promoters and differentially regulates transcription of these genes. | 29642003 |
| 2019-05-25 11:44:00 | Thus FOXF1 stimulates lung regeneration following partial pneumonectomy via direct transcriptional regulation of genes critical for extracellular matrix remodeling and cell cycle progression. | 28878348 |
| 2018-06-16 10:36:00 | It is concluded that during early pseudoglandular stage of lung development Ptch1 patterns Fgf10 and regulates Foxf1 expression in the lung mesenchyme to direct branch formation and this is essential for proper lobe formation and lung function. | 28939119 |
| Type | IDs |
|---|---|
| Synonymous | AI450827, FREAC1, Foxf1a, Freac-1, HFH-8, Hfh8 |
| Gene |
UniProtKB-ID:
FOXF1_MOUSE
UniprotKB:
Q61080
UniParc:
UPI0000218CCC
EMBL:
BC138806,
L35949,
AF346834,
BC138805,
U42556
Ensembl:
ENSMUSG00000042812
KO:
mmu:15227
|
| Nucleutide sequences |
EMBL-CDS:
AAA64885.1,
AAI38806.1,
AAK35051.1,
AAI38807.1,
AAC52445.1
Ensembl_TRS:
ENSMUST00000181504
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000137662
RefSeq:
NP_034556.2
|
| Others |
UniRef100:
UniRef100_Q61080
UniRef90:
UniRef90_Q61080
UniRef50:
UniRef50_Q12946
UniGene:
Mm.33897
CCDS:
CCDS22722.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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