| Type | Description |
|---|---|
| Definition | homeostatic iron regulator |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:13:00 | ESAT-6 Protein of Mycobacterium tuberculosis Increases Holotransferrin-Mediated Iron Uptake in Macrophages by Downregulating Surface Hemochromatosis Protein HFE. | 33148716 |
| 2020-07-11 10:30:00 | Iron accumulation in the kidneys of HFE knockout mice was associated with increase in serum and intrarenal renin expression | 31188032 |
| 2020-01-11 10:46:00 | Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype. | 31132316 |
| 2019-05-11 11:54:00 | the HFE genotype impacts the expression of tyrosine hydroxylase in the substantia nigra, the gut microbiome and the response to paraquat providing additional support that the HFE genotype is a disease modifier for Parkinson's disease | 29315562 |
| 2019-04-20 11:38:00 | the osteoporotic phenotype was only evident in Hfe-KO mice fed the iron-enriched diet. This appeared to result from an imbalance between bone formation and bone resorption driven by iron toxicity associated to Hfe-KO and confirmed by a decrease in bone microarchitecture parameters (identified by micro-CT) and osteoblast number | 30427936 |
| Type | IDs |
|---|---|
| Synonymous | MR2 |
| Gene |
UniProtKB-ID:
HFE_MOUSE,
Q5SZ87_MOUSE
UniprotKB:
P70387,
Q5SZ87
UniParc:
UPI0000020FAC,
UPI0000470CDA
EMBL:
CH466561,
BC116744,
BC116746,
AL590388,
Y12650,
AL592149,
AK009581,
U66849,
U80604,
AK150697,
AF007558
Ensembl:
ENSMUSG00000006611
KO:
mmu:15216
|
| Nucleutide sequences |
EMBL-CDS:
CAA73197.1,
EDL32544.1,
AAB51504.1,
BAB26373.1,
BAE29776.1,
AAB07525.1,
AAC03447.1,
AAI16745.1,
AAI16747.1
Ensembl_TRS:
ENSMUST00000091706,
ENSMUST00000091707
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000089298,
ENSMUSP00000089299
RefSeq:
XP_006516619.1,
NP_001334422.1,
NP_034554.2
|
| Others |
UniRef100:
UniRef100_P70387,
UniRef100_Q5SZ87
UniRef90:
UniRef90_P70387,
UniRef90_Q5SZ87
UniRef50:
UniRef50_Q30201,
UniRef50_Q9R105
UniGene:
Mm.2681
CCDS:
CCDS26360.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员