| Type | Description |
|---|---|
| Definition | pyrin domain containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 12:23:00 | POP2 inhibits inflammasome priming and activation | 28580931 |
| 2017-12-11 10:32:00 | PYDC2 inhibits NF-kB activation through the non-canonical kinase IKK epsilon. PYDC2 interferes with ASC oligomerization and with ASC-inflammasome activation resulting in reduced production of Interleukin-1-beta and reduced IL-18 secretion, as well as reduced pyroptosis. | 28580931 |
| 2008-04-21 12:58:00 | POP2 inhibits both the interaction of ASC with various NLR pyrin domains and inhibits NF-kappaB p65 (RelA). | 17339483 |
| Type | IDs |
|---|---|
| Synonymous | POP2, cPOP2 |
| Gene |
UniProtKB-ID:
PYDC2_HUMAN
UniprotKB:
Q56P42
UniParc:
UPI00001609FF
EMBL:
AY858112
Ensembl:
ENSG00000253548
KO:
hsa:152138
|
| Nucleutide sequences |
EMBL-CDS:
AAX54598.1
Ensembl_TRS:
ENST00000518817
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000492367
RefSeq:
NP_001076777.1
|
| Others |
UniRef100:
UniRef100_Q56P42
UniRef90:
UniRef90_Q56P42
UniRef50:
UniRef50_Q56P42
UniGene:
Hs.690618
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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