| Type | Description |
|---|---|
| Definition | hyperpolarization-activated, cyclic nucleotide-gated K+ 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:51:00 | The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms. | 32341127 |
| 2020-09-12 15:58:00 | Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures. | 31045576 |
| 2020-07-18 12:31:00 | Results establish that thalamic HCN4 channels are essential for the production of rhythmic intrathalamic oscillations and determine regular thalamocortical oscillatory activity during alert states. | 30877792 |
| 2020-06-13 12:23:00 | Docking experiments suggested a pivotal role of Arg-635 at the entrance of the binding pocket in HCN2, either causing stabilizing cation-pi interactions with the aromatic ring in N (6)-Phe-cAMP or N (6)-Bn-cAMP or a steric clash with the aromatic ring in N (6)-Bnz-cAMP. | 31615893 |
| 2020-05-09 11:32:00 | Pdpk1 (PDK1) and AKT are involved in the regulation of HCN2 and HCN4 mRNA transcription, protein expression, HCN current density, and cell membrane location | 32184125 |
| Type | IDs |
|---|---|
| Synonymous | BCNG2, HAC1, trls |
| Gene |
UniProtKB-ID:
HCN2_MOUSE
UniprotKB:
O88703
UniParc:
UPI0000029B3B
EMBL:
AJ225122,
AF064873
Ensembl:
ENSMUSG00000020331
KO:
mmu:15166
|
| Nucleutide sequences |
EMBL-CDS:
AAC40125.1,
CAA12406.1
Ensembl_TRS:
ENSMUST00000020581,
ENSMUST00000099513
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000020581,
ENSMUSP00000097113
RefSeq:
NP_032252.1
|
| Others |
UniRef100:
UniRef100_O88703
UniRef90:
UniRef90_O88703
UniRef50:
UniRef50_O88703
UniGene:
Mm.12956
CCDS:
CCDS23986.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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