| Type | Description |
|---|---|
| Definition | hyperpolarization-activated, cyclic nucleotide-gated K+ 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 11:53:00 | The ionic mechanism driving increased excitability involves alterations of the expression levels of HCN and KCNQ channel genes leading to a complex dynamic of H-current and M-current activation. Moreover, there is a negative correlation between the disease onset and disease progression, which correlates with a decrease in the expression level of HCN and KCNQ channels. | 30952836 |
| 2019-11-02 10:11:00 | A mutant channel containing just five mutations (M485I, G497D, S514T, V562A, and S563G) switches cAMP sensitivity of full-length HCN2 to that of HCN1 channels. | 29980633 |
| 2019-08-24 12:19:00 | Study found stronger h-channel (HCN1)-related membrane properties in supragranular pyramidal neurons in human temporal cortex, compared to mouse supragranular pyramidal neurons in temporal association area. H-channels contribute to between-species differences in a fundamental neuronal property. | 30392798 |
| 2019-06-08 10:38:00 | spatially distributed actions of HCN1 channels enable the inferior olive to implement network-wide rules for synaptic integration that modulate the timing of cerebellar climbing fiber signals. | 29444426 |
| 2019-01-12 12:29:00 | a regulatory role of HCN1 on Cav3.2 voltage-dependent properties | 28467171 |
| Type | IDs |
|---|---|
| Synonymous | Bcng1, C630013B14Rik, HAC2 |
| Gene |
UniProtKB-ID:
HCN1_MOUSE
UniprotKB:
O88704
UniParc:
UPI0000020FD6
EMBL:
AK014722,
AJ225123,
AF028737
Ensembl:
ENSMUSG00000021730
KO:
mmu:15165
|
| Nucleutide sequences |
EMBL-CDS:
CAA12407.1,
AAC53518.1
Ensembl_TRS:
ENSMUST00000006991
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000006991
RefSeq:
NP_034538.2
|
| Others |
UniRef100:
UniRef100_O88704
UniRef90:
UniRef90_O60741
UniRef50:
UniRef50_O60741
UniGene:
Mm.343429
CCDS:
CCDS26793.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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