| Type | Description |
|---|---|
| Definition | deltex E3 ubiquitin ligase 3L |
| Date | Results | Publications |
|---|---|---|
| 2018-06-02 10:46:00 | Immunohistochemical analysis demonstrated that DTX3L was highly expressed in the glioma tissues and its level was correlated with the grade of malignancy. Multivariate analysis revealed the association between high expression of DTX3L and the poor prognosis of glioma patients. In addition, knockdown of DTX3L by siRNA transfection increased glioma cell apoptosis. | 28627634 |
| 2017-09-09 12:04:00 | Dtx3L heterodimerization with Parp9 enables NAD(+) and poly(ADP-ribose) regulation of E3 activity. | 28525742 |
| 2017-07-15 10:41:00 | we also found that DTX3L expression was regulated by focal adhesion kinase. Taken together, the results of this study show that DTX3L plays an important role in the proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells and as such may play a key role in the development of multiple myeloma. | 28653881 |
| 2015-01-31 13:16:00 | A novel role for the really interesting new gene-domain E3 ubiquitin ligase deltex-3-like (DTX3L) in regulating CXCR4 sorting from endosomes to lysosomes. | 24790097 |
| 2014-12-20 10:15:00 | The present study further suggests that the combined targeted inhibition of ARTD8, ARTD9 and/or DTX3L could increase the efficacy of chemotherapy or radiation treatment in prostate and other high-risk tumor types with an increased signaling. | 24886089 |
| Type | IDs |
|---|---|
| Synonymous | BBAP, RNF143 |
| Gene |
UniProtKB-ID:
DTX3L_HUMAN
UniprotKB:
Q8TDB6
UniParc:
UPI00004DF106,
UPI000000D9D0
EMBL:
AY780792,
BC042191,
AY225123,
BC060509,
AF484416,
AK125086,
CH471052
Ensembl:
ENSG00000163840
KO:
hsa:151636
|
| Nucleutide sequences |
EMBL-CDS:
AAH42191.1,
BAG54138.1,
AAL90859.1,
AAH60509.1,
AAV98362.1,
AAP57517.1,
EAW79476.1
Ensembl_TRS:
ENST00000296161,
ENST00000383661
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000296161,
ENSP00000373157
RefSeq:
NP_612144.1
|
| Others |
UniRef100:
UniRef100_Q8TDB6
UniRef90:
UniRef90_Q8TDB6
UniRef50:
UniRef50_Q8TDB6
UniGene:
Hs.518201
CCDS:
CCDS3015.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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