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151246 SGO2

151246

SGO2

shugoshin 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition shugoshin 2

研究结论

Date Results Publications
2020-06-06 12:45:00 results identify an unexpected function of SGO2 in mitotically dividing cells and a mechanism of separase regulation that is independent of securin but still supervised by the spindle assembly checkpoint 32322060
2020-05-16 11:22:00 The SET localizes at the inner centromere by interacting directly with SGO2, with SET levels declining at increased distances between kinetochore pairs, leading to establishment of chromosome bi-orientation. 31527146
2018-07-23 13:18:00 Results from a study on gene expression variability markers in early-stage human embryos shows that SGO2 is a putative expression variability marker for the 3-day, 8-cell embryo stage. 26288249
2017-09-30 10:43:00 Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression. 28781233
2017-07-01 12:04:00 In mouse, Sgol2a encoding shugoshin-like 2a is necessary during meiosis in both sexes to maintain the integrity of the cohesin complex that tethers sister chromatids. Human SGO2 has not previously been implicated in any disorder, but in this case of POI and perhaps others, it is a candidate for unexplained infertility 27629923

名称对应

Type IDs
Synonymous SGOL2, TRIPIN
Gene
UniProtKB-ID: SGO2_HUMAN, B7Z7S9_HUMAN
UniprotKB: Q562F6, B7Z7S9
UniParc: UPI00019151EF, UPI00001AEBF5, UPI0000171C6D, UPI0000209354
EMBL: AK057940, AY094614, BC092412, AC012459, AK095291, BC035764, BX647433, BC048349, AC080164, AK302457
Ensembl: ENSG00000163535
KO: hsa:151246
Nucleutide sequences
EMBL-CDS: AAH92412.1, AAM21971.1, AAH35764.1, BAC04524.1, AAY24310.1, BAB71617.1, AAH48349.1, AAY24264.1, BAH13715.1
Ensembl_TRS: ENST00000409203, ENST00000357799
Protein sequencees
Ensembl_PRO: ENSP00000386249, ENSP00000350447
RefSeq: XP_016858941.1, XP_016858943.1, NP_001153505.1, XP_016858942.1, XP_005246401.2, XP_011509036.1, NP_001153518.1, NP_689737.4, XP_005246402.1
Others
UniRef100: UniRef100_B7Z7S9, UniRef100_Q562F6
UniRef90: UniRef90_Q562F6
UniRef50: UniRef50_Q562F6
UniGene: Hs.655182
CCDS: CCDS42796.1

全选

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