| Type | Description |
|---|---|
| Definition | cathepsin H |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 12:16:00 | Study presents the crystal structures of human procathepsin H at 2.00 A and 1.66 A resolution. These structures allow us to explore in detail the molecular basis for the inhibition of the mature domain by the prodomain. Comparison with cathepsin H structure reveals how mini-chain reorients upon activation. Results demonstrate that procathepsin H is not auto-activated but can be trans-activated by cathepsin L. | 30044821 |
| 2017-05-27 11:04:00 | the up-regulation of MMP genes is mediated through degradation of class IIa histone deacetylases (HDACs) by certain cysteine cathepsins (Cts). | 28157489 |
| 2016-08-13 12:07:00 | Especially, rs3825932 in CTSH has integrative functional evidence supporting the association with type 1 diabetes mellitus. | 26429317 |
| 2016-07-30 10:28:00 | p41 fragment is also shown to reduce the secretion of interleukin-12 (IL-12/p70) during the subsequent maturation of treated dendritic cells. | 26960148 |
| 2016-05-28 10:06:00 | In conclusion, CTSH/rs3825932 and ERBB3/rs2292239 SNPs were associated with reduced risk of progression to proliferative diabetic retinopathy and two-step progression of diabetic retinopathy on the ETDRS scale accordingly. | 26245339 |
| Type | IDs |
|---|---|
| Synonymous | ACC-4, ACC-5, ACC4, ACC5, CPSB |
| Gene |
UniProtKB-ID:
CATH_HUMAN
UniprotKB:
P09668
UniParc:
UPI000013C799
EMBL:
BC002479,
X16832,
AK314698,
X07549,
AF426247,
AC011944
Ensembl:
ENSG00000103811
KO:
hsa:1512
|
| Nucleutide sequences |
EMBL-CDS:
CAA34734.1,
BAG37247.1,
AAH02479.1,
CAA30429.1,
AAL23961.1,
CAA30428.1
Ensembl_TRS:
ENST00000220166
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000220166
RefSeq:
XP_024305621.1,
XP_016877441.1,
XP_024305620.1,
XP_005254238.1,
XP_024305623.1,
NP_004381.2,
NP_001306066.1,
XP_024305622.1,
XP_016877440.1
|
| Others |
UniRef100:
UniRef100_P09668
UniRef90:
UniRef90_P09668
UniRef50:
UniRef50_P09668
UniGene:
Hs.148641
CCDS:
CCDS10308.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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