| Type | Description |
|---|---|
| Definition | huntingtin-associated protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 13:03:00 | Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice. | 32747555 |
| 2020-08-12 15:35:00 | our results identify HAP1 as an in vivo UBE3A target that contributes to deregulated autophagy and synaptic dysfunction in the central nervous system of Angelman syndrome mice | 31445164 |
| 2019-05-25 12:08:00 | HAP1 plays a role in the endocytosis of BDNF and its receptor in neurons. | 28083816 |
| 2018-04-28 10:43:00 | Depleting Huntingtin-associated protein 1 (Hap1) promoted the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)-DDB1 and CUL4 associated factor 7 (Dcaf7) interaction and increased the DYRK1A protein level. | 28137862 |
| 2018-02-24 10:33:00 | This study also validated the interaction between HAP1 and Sec23A using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins | 28259758 |
| Type | IDs |
|---|---|
| Synonymous | HAP-1 |
| Gene |
UniProtKB-ID:
HAP1_MOUSE
UniprotKB:
O35668
UniParc:
UPI00000299F7,
UPI0000028207
EMBL:
AJ002271,
BC053043,
BC034089,
AJ003128,
AJ000262
Ensembl:
ENSMUSG00000006930
KO:
mmu:15114
|
| Nucleutide sequences |
EMBL-CDS:
AAH34089.1,
CAA05286.1,
AAH53043.1,
CAA03978.1,
CAA05883.1
Ensembl_TRS:
ENSMUST00000138603,
ENSMUST00000103124
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000133356,
ENSMUSP00000099413
RefSeq:
NP_034534.1,
NP_001345981.1,
XP_030101441.1,
XP_011247047.1,
NP_817090.1,
XP_030101440.1,
XP_011247046.1
|
| Others |
UniRef100:
UniRef100_O35668
UniRef90:
UniRef90_P54256
UniRef50:
UniRef50_P54256
UniGene:
Mm.281700
CCDS:
CCDS56806.1,
CCDS25419.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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