| Type | Description |
|---|---|
| Definition | histocompatibility 2, O region beta locus |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:56:00 | Mouse MHC class II chaperone H2-O antigen affects the repertoire of presented self-peptides by B cells and thymic epithelium. H2-O induces differential effects on epitope presentation and thymic selection, thereby altering CD4 T-cell precursor frequencies. Lack of H2-O increases autoreactivity and susceptibility to autoimmune disease development. | 32069316 |
| 2017-09-30 12:14:00 | these results report positional cloning of the gene responsible for production of retrovirus-neutralizing antibodies in mice of the I/LnJ strain; it encodes the beta subunit of the non-classical major histocompatibility complex class II (MHC-II)-like molecule H2-O, a negative regulator of antigen presentation | 28813660 |
| 2010-01-21 00:00:00 | H2-O predominantly inhibits antigen presentation in early endosomal compartments. Thus, H2-O appears to skew peptide loading to late endosomal/lysosomal compartments. This may favor presentation of antigens taken up by the B cell receptor. | 12645938 |
| Type | IDs |
|---|---|
| Synonymous | A-beta-2, A-beta2, H-2Ab, H-2I, H-2Ob, H2-Ab, H2-Ab2, H2-IAb2, Ob, vic1 |
| Gene |
UniProtKB-ID:
Q3U1X7_MOUSE,
O35424_MOUSE
UniprotKB:
Q3U1X7,
O35424
UniParc:
UPI00005ACEB5,
UPI00000E71B7
EMBL:
CR974422,
AK155144,
AK155650,
AF027865
Ensembl:
ENSMUSG00000041538
KO:
mmu:15002
|
| Nucleutide sequences |
EMBL-CDS:
BAE33366.1,
BAE33074.1,
AAB81530.1
Ensembl_TRS:
ENSMUST00000095342
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000092985
RefSeq:
XP_006523749.1,
NP_034519.2
|
| Others |
UniRef100:
UniRef100_Q3U1X7,
UniRef100_O35424
UniRef90:
UniRef90_Q3U1X7
UniRef50:
UniRef50_Q3U1X7
UniGene:
Mm.327358
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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