| Type | Description |
|---|---|
| Definition | histocompatibility 2, O region alpha locus |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:56:00 | Mouse MHC class II chaperone H2-O antigen affects the repertoire of presented self-peptides by B cells and thymic epithelium. H2-O induces differential effects on epitope presentation and thymic selection, thereby altering CD4 T-cell precursor frequencies. Lack of H2-O increases autoreactivity and susceptibility to autoimmune disease development. | 32069316 |
| 2010-01-21 00:00:00 | H2-O predominantly inhibits antigen presentation in early endosomal compartments. Thus, H2-O appears to skew peptide loading to late endosomal/lysosomal compartments. This may favor presentation of antigens taken up by the B cell receptor. | 12645938 |
| 2010-01-21 00:00:00 | investigated H2-O, H2-M, and I-A(b)-CLIP expression patterns in B cell subsets during B cell development and activation | 17237397 |
| Type | IDs |
|---|---|
| Synonymous | H-2Oa |
| Gene |
UniProtKB-ID:
B2RST7_MOUSE,
Q9QWV1_MOUSE
UniprotKB:
B2RST7,
Q9QWV1
UniParc:
UPI0000022303,
UPI0001747A48
EMBL:
AF100956,
BC138996,
CR974462,
BC138997,
AK020594,
AK170742
Ensembl:
ENSMUSG00000024334
KO:
mmu:15001
|
| Nucleutide sequences |
EMBL-CDS:
AAI38997.1,
AAI38998.1,
BAB32142.1,
BAE41995.1,
AAC69906.1
Ensembl_TRS:
ENSMUST00000025192
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025192
RefSeq:
NP_032232.2,
XP_036016223.1
|
| Others |
UniRef100:
UniRef100_Q9QWV1,
UniRef100_B2RST7
UniRef90:
UniRef90_Q9QWV1
UniRef50:
UniRef50_P20037
UniGene:
Mm.116
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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