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14977 Slc39a7

14977

Slc39a7

solute carrier family 39 (zinc transporter), member 7

protein-coding

Mus musculus

基因描述

Type Description
Definition solute carrier family 39 (zinc transporter), member 7

研究结论

Date Results Publications
2020-01-18 12:08:00 we have clarified the functional differences between ZIP7 and ZIP13 and show that their different regulation of cellular zinc homeostasis is critical for dermal development and homeostasis. 31412620
2020-01-04 11:31:00 Study identified that Zip7 is upregulated by glucose in normal skeletal muscle cells and downregulated in insulin-resistant skeletal muscle. The overexpression of Zip7 in skeletal muscle cells led to the modulation of key genes involved in the insulin signaling axis and glucose metabolism. In vivo mouse model revealed a reduction in Glut4 and Zip7 in the skeletal muscle of mice fed a high-fat diet. 31266232
2019-11-02 10:41:00 Depletion of zinc transporter Zip7 by RNA interference shows reduction of both PI3K/Akt signalling and a significant reduction of multinucleated myofibres and myotubes development. Moreover, we show that mature myofibres, obtained through stimulation with high concentrations of zinc, accumulate zinc and so we hypothesise their function as zinc reservoirs into the cell 30206294
2017-05-13 16:06:00 these findings provide evidence for the importance of ZIP7 in maintenance of intestinal epithelial homeostasis through the regulation of ER function in proliferative progenitor cells and maintenance of intestinal stem cells. Therapeutic targeting of ZIP7 could lead to effective treatment of gastrointestinal disorders. 27736879
2014-09-06 11:37:00 a novel role for Zip7 in glucose metabolism in skeletal muscle 24265765

名称对应

Type IDs
Synonymous AA408174, AI117660, AL024048, H-2Ke4, H2-Ke4, Ke-4, Ke4, Ring5, Zip7
Gene
UniProtKB-ID: S39A7_MOUSE, A0A068BIT0_MOUSE
UniprotKB: Q31125, A0A068BIT0
UniParc: UPI00000222FD
EMBL: M32010, KJ650218, AF100956, AK159968
Ensembl: ENSMUSG00000024327
KO: mmu:14977
Nucleutide sequences
EMBL-CDS: BAE35522.1, AAC69903.1, AAA37767.1, AIC84006.1
Ensembl_TRS: ENSMUST00000025186, ENSMUST00000169397
Protein sequencees
Ensembl_PRO: ENSMUSP00000025186, ENSMUSP00000130102
RefSeq: NP_001071177.1, NP_032228.2
Others
UniRef100: UniRef100_Q31125
UniRef90: UniRef90_Q31125
UniRef50: UniRef50_Q92504
UniGene: Mm.18556
CCDS: CCDS37576.1

全选

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