| Type | Description |
|---|---|
| Definition | guanylate cyclase activator 2a (guanylin) |
| Date | Results | Publications |
|---|---|---|
| 2018-12-29 10:19:00 | Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes. | 29289697 |
| 2017-07-08 13:04:00 | guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage | 27246004 |
| 2010-01-21 00:00:00 | These findings suggest that guanylin deficiency causes basal chloride secretion and reduced responsiveness to heat stable enterotoxin (STa) in mouse proximal colon. | 15026148 |
| 2010-01-21 00:00:00 | act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes | 14675035 |
| 2010-01-21 00:00:00 | existence of two signaling pathways for guanylin peptides in principal cells of mouse cortical collecting duct of kidney | 16105031 |
| Type | IDs |
|---|---|
| Synonymous | Guca2 |
| Gene |
UniProtKB-ID:
GUC2A_MOUSE
UniprotKB:
P33680
UniParc:
UPI000000191A
EMBL:
BC012640,
AK075814,
L05516,
U60528,
M95175
Ensembl:
ENSMUSG00000023247
KO:
mmu:14915
|
| Nucleutide sequences |
EMBL-CDS:
AAH12640.1,
BAC35981.1,
AAB05758.1,
AAA37715.1,
AAA37758.1
Ensembl_TRS:
ENSMUST00000024015
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000024015
RefSeq:
NP_032216.1
|
| Others |
UniRef100:
UniRef100_P33680
UniRef90:
UniRef90_P33680
UniRef50:
UniRef50_P28902
UniGene:
Mm.2614
CCDS:
CCDS18586.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29684311 |
TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol Manasa Srivillibhuthur , Bailey N Warder , Natalie H Toke , Pooja P Shah , Qiang Feng , Nan Gao , Edward M Bonder , Michael P Verzi |
2018-07-15 | - |
| 29289697 |
Peptides MarÃa L Fernandez-Cachon , Søren L Pedersen , Kristoffer T Rigbolt , Chen Zhang , Katrine Fabricius , Henrik H Hansen , Lisbeth Elster , Lisbeth N Fink , Matthias Schäfer , Nicolai A Rhee , Ebbe Langholz , Erik Wandall , Steffen U Friis , Peter Vilmann , Viggo B Kristiansen , Christina Schmidt , Kay Schreiter , Kristin Breitschopf , Thomas Hübschle , Tina Jorsal , Tina Vilsbøll , Thorsten Schmidt , Stefan Theis , Filip K Knop , Philip Just Larsen , Jacob Jelsing |
2018-03-01 | - |
| 27246004 |
Histochem. Cell Biol. Pauline T Ikpa , Hein F B M Sleddens , Kris A Steinbrecher , Maikel P Peppelenbosch , Hugo R de Jonge , Ron Smits , Marcel J C Bijvelds |
2016-10-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21555532 |
Murine guanylate cyclase C regulates colonic injury and inflammation. J Immunol Kris A Steinbrecher , Eleana Harmel-Laws , Monica P Garin-Laflam , Elizabeth A Mann , Lucas D Bezerra , Simon P Hogan , Mitchell B Cohen |
2011-06-15 | - |
| 21267068 |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. Graciana Diez-Roux , Sandro Banfi , Marc Sultan , Lars Geffers , Santosh Anand , David Rozado , Alon Magen , Elena Canidio , Massimiliano Pagani , Ivana Peluso , Nathalie Lin-Marq , Muriel Koch , Marchesa Bilio , Immacolata Cantiello , Roberta Verde , Cristian De Masi , Salvatore A Bianchi , Juliette Cicchini , Elodie Perroud , Shprese Mehmeti , Emilie Dagand , Sabine Schrinner , Asja Nürnberger , Katja Schmidt , Katja Metz , Christina Zwingmann , Norbert Brieske , Cindy Springer , Ana Martinez Hernandez , Sarah Herzog , Frauke Grabbe , Cornelia Sieverding , Barbara Fischer , Kathrin Schrader , Maren Brockmeyer , Sarah Dettmer , Christin Helbig , Violaine Alunni , Marie-Annick Battaini , Carole Mura , Charlotte N Henrichsen , Raquel Garcia-Lopez , Diego Echevarria , Eduardo Puelles , Elena Garcia-Calero , Stefan Kruse , Markus Uhr , Christine Kauck , Guangjie Feng , Nestor Milyaev , Chuang Kee Ong , Lalit Kumar , MeiSze Lam , Colin A Semple , Attila Gyenesei , Stefan Mundlos , Uwe Radelof , Hans Lehrach , Paolo Sarmientos , Alexandre Reymond , Duncan R Davidson , Pascal Dollé , Stylianos E Antonarakis , Marie-Laure Yaspo , Salvador Martinez , Richard A Baldock , Gregor Eichele , Andrea Ballabio |
2011-01-18 | - |
| 16971476 |
Development Michael Y Choi , Anthony I Romer , Michael Hu , Maina Lepourcelet , Ambili Mechoor , Ayce Yesilaltay , Monty Krieger , Paul A Gray , Ramesh A Shivdasani |
2006-10-01 |
Tbx10,
Hoxc11,
Nr3c2,
Adh1,
Nr0b1,
Nr2f2,
Ar,
Atoh1,
Barx2,
Car1,
Nr1i3,
Cdx1,
Cdx2,
Ehf,
Ephx2,
Nr2f1,
Esr1,
Esr2,
Nr6a1,
Nr3c1,
Guca2a,
Hes2,
Foxq1,
Hhex,
Nr4a1,
Hnf4a,
Hoxa1,
Hoxa10,
Hoxa11,
Hoxa13,
Hoxa2,
Hoxa3,
Hoxa4,
Hoxa5,
Hoxa6,
Hoxa7,
Hoxa9,
Hoxb1,
Hoxb13,
Hoxb3,
Hoxb4,
Hoxb5,
Hoxb6,
Hoxb7,
Hoxb8,
Hoxb9,
Hoxc12,
Hoxc4,
Hoxc5,
Hoxc6,
Hoxc8,
Hoxc9,
Hoxd1,
Hoxd10,
Hoxd11,
Hoxd12,
Hoxd13,
Hoxd3,
Hoxd4,
Hoxd9,
Bhlha15,
Nfe2l2,
Nkx6-1,
Nr4a3,
Nr1i2,
Reg3b,
Pax4,
Pbx1,
Plau,
Prrx1,
Pou2f3,
Ppara,
Pparg,
Rhox6,
Rarg,
Rnf4,
Rora,
Rorc,
Rxra,
Rxrb,
Nr1h4,
Scx,
Slc2a2,
Sox15,
Scarb1,
Tbx5,
Tcf20,
Tcf3,
Tfec,
Nr1d1,
Thrb,
Rarb,
Nr2e1,
Nr2c1,
Nr1h3,
Nr1h2,
Vdr,
Zfp52,
Zfp62
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 16105031 |
Kidney Int. Aleksandra SindiÄ , Ana Velic , Candan BaÅoglu , Jochen R Hirsch , Bayram Edemir , Michaela Kuhn , Eberhard Schlatter |
2005-09-01 |
Guca2a,
Guca2b,
Gucy2c
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员