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14913 Guca1a

14913

Guca1a

guanylate cyclase activator 1a (retina)

protein-coding

Mus musculus

基因描述

Type Description
Definition guanylate cyclase activator 1a (retina)

研究结论

Date Results Publications
2021-01-16 15:59:00 GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress. 31980596
2019-01-26 12:40:00 conclude that, under normal physiological conditions, GCAP1 dominates the regulation of cGMP synthesis in mouse cones, but if its function becomes compromised, GCAP2 contributes to the regulation of phototransduction and light adaptation of cones 29549122
2015-05-30 12:14:00 The GCAP1 and GCAP2 binding site(s) overlaps within the kinase homology and/or dimerization domains of retinal GC1. 25616661
2015-05-09 12:35:00 Direct association between RD3 and GCAP1 is important for GC1 targeting. 25477517
2014-11-22 12:30:00 The wild type and mutants of GCAP1 displayed large differences in Ca(2+)-binding and regulation and preserved an intact secondary and tertiary structure with a significant rearrangement of the aromatic residues upon binding of Ca(2+). 24566882

名称对应

Type IDs
Synonymous GC-A, Gcap1, Guca1, mGCAP1
Gene
UniProtKB-ID: GUC1A_MOUSE
UniprotKB: P43081
UniParc: UPI00000E7F4D
EMBL: BC031810, L36860, AC112683, CH466559, BC026834
Ensembl: ENSMUSG00000116418, ENSMUSG00000023982
KO: mmu:14913
Nucleutide sequences
EMBL-CDS: EDL23560.1, AAA60716.1, EDL23559.1, AAH31810.1, EDL23558.1, AAH26834.1
Ensembl_TRS: ENSMUST00000059348, ENSMUST00000229460
Protein sequencees
Ensembl_PRO: ENSMUSP00000154831, ENSMUSP00000060027
RefSeq: NP_032215.2, XP_011244598.1
Others
UniRef100: UniRef100_P43081
UniRef90: UniRef90_P43081
UniRef50: UniRef50_P43080
UniGene: Mm.16224
CCDS: CCDS28848.1

全选

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