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An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.

Nat Genet     Siwei Chen , Robert Fragoza , Lambertus Klei , Yuan Liu , Jiebiao Wang , Kathryn Roeder , Bernie Devlin , Haiyuan Yu

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination.

BMC Biol     Nila Roy Choudhury , Gregory Heikel , Maryia Trubitsyna , Peter Kubik , Jakub Stanislaw Nowak , Shaun Webb , Sander Granneman , Christos Spanos , Juri Rappsilber , Alfredo Castello , Gracjan Michlewski

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

Cell Rep     Timothy D Martin , Danielle R Cook , Mei Yuk Choi , Mamie Z Li , Kevin M Haigis , Stephen J Elledge

Architecture of the human interactome defines protein communities and disease networks.

Nature     Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

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A proteome-scale map of the human interactome network.

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