| Type | Description |
|---|---|
| Definition | heat shock protein 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 10:34:00 | Grp78 deletion caused weight loss, mortality, lung inflammation, and spatially heterogeneous fibrosis characterized by fibroblastic foci, hyperplastic AT2 cells, and increased susceptibility of old and male mice, all features of IPF. These results support a causal role for ER stress and resulting epithelial dysfunction in PF and suggest ER stress as a potential mechanism linking aging to IPF. | 31738079 |
| 2020-01-11 11:44:00 | Ca2+ dependent CaMKII activation fosters Doxorubicin cardiomyopathy and provide additional insight into possible mechanisms by which GRP78 overexpression protects cardiomyocytes from Doxorubicin toxicity. | 31034488 |
| 2020-01-11 10:39:00 | our study demonstrated that miR-181b could attenuate brain injury through down-regulating protein levels in vitro and in vivo. | 30503822 |
| 2019-12-14 10:13:00 | work reveals a role for csGRP78 in high glucose-induced profibrotic responses in mesangial cells, informing a potential approach to treating diabetic nephropathy. | 30914477 |
| 2019-11-23 10:17:00 | GRP78 increases GATA4 (GATA-binding protein 4) level, which may stimulate Anf (atrial natriuretic factor) expression and promote cardiac hypertrophic growth. | 30580686 |
| Type | IDs |
|---|---|
| Synonymous | AL022860, AU019543, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, SEZ-7, Sez7, baffled, mBiP |
| Gene |
UniProtKB-ID:
BIP_MOUSE,
Q3U7T8_MOUSE
UniprotKB:
P20029,
Q3U7T8
UniParc:
UPI00005ACBEE,
UPI00000040FD
EMBL:
AJ002387,
AK148539,
AK152521,
AK152020,
D78645,
AK166739,
BC050927,
AK076079,
M19351,
M30779,
AK169034,
U16277,
AK151647,
AK146647
Ensembl:
ENSMUSG00000026864
KO:
mmu:14828
|
| Nucleutide sequences |
EMBL-CDS:
BAA11462.1,
AAA37742.1,
AAA76734.1,
BAE38982.1,
BAE30576.1,
BAE28609.1,
AAH50927.1,
BAE30882.1,
AAA37315.1,
BAE40825.1,
CAA05361.1,
BAC36166.1,
BAE27328.1,
BAE31281.1
Ensembl_TRS:
ENSMUST00000100171,
ENSMUST00000028222
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028222,
ENSMUSP00000097747
RefSeq:
NP_071705.3,
NP_001156906.1
|
| Others |
UniRef100:
UniRef100_P20029
UniRef90:
UniRef90_P11021
UniRef50:
UniRef50_P11021
UniGene:
Mm.330160,
Mm.470180
CCDS:
CCDS15950.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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