| Type | Description |
|---|---|
| Definition | zinc and ring finger 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 11:50:00 | ZNRF4 is a negative regulator of NOD2 and NF-kappaB. ZNRF4 promotes K48-linked ubiquitination of RIP2.ZNRF4 role in the protective host immunity. | 28656966 |
| 2011-05-14 10:46:00 | Nixin/ZNRF4 to be central for the regulation of calnexin turnover. | 21205830 |
| 2004-04-05 15:18:00 | Characterization and study of mouse homolog. | 10191088 |
| Type | IDs |
|---|---|
| Synonymous | RNF204, SPERIZIN, Ssrzf1, spzn |
| Gene |
UniProtKB-ID:
ZNRF4_HUMAN
UniprotKB:
Q8WWF5
UniParc:
UPI0000366CF5
EMBL:
AK292251,
BC017592,
AC005764,
CH471139
Ensembl:
ENSG00000105428
KO:
hsa:148066
|
| Nucleutide sequences |
EMBL-CDS:
BAF84940.1,
AAC62428.1,
EAW69169.1,
AAH17592.2
Ensembl_TRS:
ENST00000222033
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000222033
RefSeq:
NP_859061.3
|
| Others |
UniRef100:
UniRef100_Q8WWF5
UniRef90:
UniRef90_Q8WWF5
UniRef50:
UniRef50_Q8WWF5
UniGene:
Hs.126496
CCDS:
CCDS42475.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 28656966 |
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. Nat Commun Pradeep Bist , Wan Shoo Cheong , Aylwin Ng , Neha Dikshit , Bae-Hoon Kim , Niyas Kudukkil Pulloor , Hanif Javanmard Khameneh , Matija Hedl , Avinash R Shenoy , Vanniarajan Balamuralidhar , Najib Bin Abdul Malik , Michelle Hong , Albert Neutzner , Keh-Chuang Chin , Koichi S Kobayashi , Antonio Bertoletti , Alessandra Mortellaro , Clara Abraham , John D MacMicking , Ramnik J Xavier , Bindu Sukumaran |
2017-06-28 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21205830 |
J Biol Chem Albert Neutzner , Melanie Neutzner , Anne-Sophie Benischke , Seung-Wook Ryu , Stephan Frank , Richard J Youle , Mariusz Karbowski |
2011-03-11 | - |
| 19690564 |
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol. Syst. Biol. Sjoerd J L van Wijk , Sjoerd J de Vries , Patrick Kemmeren , Anding Huang , Rolf Boelens , Alexandre M J J Bonvin , H Th Marc Timmers |
2009-01-01 |
TRIM28,
RNF41,
TOPORS,
TRAIP,
TRIM38,
UBE2E3,
TRIM3,
CGRRF1,
MID2,
UBE2C,
RNF139,
BIRC8,
RNF13,
RNF157,
UHRF2,
RNF166,
RFFL,
TRIM43,
RNF113B,
MIB2,
ZNRF4,
UBE2U,
ZSWIM2,
SH3RF2,
RNF168,
DTX1,
TRIM65,
RNF152,
RNF182,
ZNRF2,
TRIM32,
TRIM35,
MGRN1,
TRIM2,
RNF144B,
RNF167,
LTN1,
AMFR,
RNF11,
VPS41,
RNF115,
UBE2T,
BIRC2,
BIRC3,
MDM2,
MAP3K1,
TRIM37,
NFX1,
CNOT4,
RNF165,
RNFT1,
RNF181,
BFAR,
UBE2J1,
ANAPC11,
UFM1,
UBE2D4,
PML,
TRIM34,
RNF186,
RNF111,
RNF43,
TRIM68,
RFWD3,
UBE2W,
UBE2Q1,
RNF130,
RNF114,
RNF17,
TRIM54,
RNF150,
MIB1,
BARD1,
RNF2,
RNF4,
RNF5,
IRF2BPL,
PJA1,
RNF25,
SIAH1,
RMND5B,
UBE2Z,
HLTF,
BRCA1,
UBE2D1,
UBE2D2,
UBE2D3,
UBE2E1,
UBE2E2,
UBE2G2,
UBE2H,
UBE2N,
PCGF2,
RNF113A,
RNF103,
RNF26,
MUL1,
RNF122,
KAT6A
|
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 15057824 |
The DNA sequence and biology of human chromosome 19. Nature Jane Grimwood , Laurie A Gordon , Anne Olsen , Astrid Terry , Jeremy Schmutz , Jane Lamerdin , Uffe Hellsten , David Goodstein , Olivier Couronne , Mary Tran-Gyamfi , Andrea Aerts , Michael Altherr , Linda Ashworth , Eva Bajorek , Stacey Black , Elbert Branscomb , Sean Caenepeel , Anthony Carrano , Chenier Caoile , Yee Man Chan , Mari Christensen , Catherine A Cleland , Alex Copeland , Eileen Dalin , Paramvir Dehal , Mirian Denys , John C Detter , Julio Escobar , Dave Flowers , Dea Fotopulos , Carmen Garcia , Anca M Georgescu , Tijana Glavina , Maria Gomez , Eidelyn Gonzales , Matthew Groza , Nancy Hammon , Trevor Hawkins , Lauren Haydu , Isaac Ho , Wayne Huang , Sanjay Israni , Jamie Jett , Kristen Kadner , Heather Kimball , Arthur Kobayashi , Vladimer Larionov , Sun-Hee Leem , Frederick Lopez , Yunian Lou , Steve Lowry , Stephanie Malfatti , Diego Martinez , Paula McCready , Catherine Medina , Jenna Morgan , Kathryn Nelson , Matt Nolan , Ivan Ovcharenko , Sam Pitluck , Martin Pollard , Anthony P Popkie , Paul Predki , Glenda Quan , Lucia Ramirez , Sam Rash , James Retterer , Alex Rodriguez , Stephanine Rogers , Asaf Salamov , Angelica Salazar , Xinwei She , Doug Smith , Tom Slezak , Victor Solovyev , Nina Thayer , Hope Tice , Ming Tsai , Anna Ustaszewska , Nu Vo , Mark Wagner , Jeremy Wheeler , Kevin Wu , Gary Xie , Joan Yang , Inna Dubchak , Terrence S Furey , Pieter DeJong , Mark Dickson , David Gordon , Evan E Eichler , Len A Pennacchio , Paul Richardson , Lisa Stubbs , Daniel S Rokhsar , Richard M Myers , Edward M Rubin , Susan M Lucas |
2004-04-01 |
ZGLP1,
C19orf71,
ZNF725P,
TMEM221,
SBK3,
SNRPGP15,
BSPH1,
KIR2DS2,
LOC100134317,
ERICH4,
MEF2B,
ZNF729,
ZNF861P,
GFY,
ZNF865,
ERVS71-1,
SUGP2,
EBI3,
AKAP8,
HMG20B,
KLF1,
CERS1,
CEACAM7,
CEACAM8,
UQCR11,
KLK11,
TMED1,
UPK1A,
KLK8,
PNKP,
COPE,
CIRBP,
TBCB,
ARHGAP33,
CKM,
GRIN3B,
CLC,
CCDC159,
MOB3A,
GIPC3,
OR1I1,
HSPB6,
COMP,
COX6B1,
COX7A1,
CSNK1G2,
NCAN,
ZNRF4,
ZNF98,
DIRAS1,
CYP2B6,
AP2A1,
ZNF550,
ZNF780B,
AES,
DMWD,
DNASE2,
DNM2,
DNMT1,
ARID3A,
EFNA2,
NLRP7,
ERF,
FBL,
ETV2,
FARSA,
MAST1,
KDM4B,
MAST3,
CIC,
CRTC1,
PIP5K1C,
ETHE1,
BRD4,
FPR1,
FPR2,
FKBP8,
CBARP,
C19orf38,
SYCE2,
SHC2,
GAMT,
KLK13,
PRPF31,
GAPDHS,
OR7A17,
GCDH,
OR10H3,
OR10H2,
OR10H1,
GDF1,
OR7E24,
OR7C2,
OR7A5,
OR7C1,
AMH,
GIPR,
LYPD3,
TJP3
|
| 12477932 |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team |
2002-12-24 | - |
| 10191088 |
Sperizin is a murine RING zinc-finger protein specifically expressed in Haploid germ cells. Genomics T Fujii , K Tamura , N G Copeland , D J Gilbert , N A Jenkins , K Yomogida , H Tanaka , Y Nishimune , H Nojima , Y Abiko |
1999-04-01 |
Fert1,
Tic1,
Znrf4,
Vav1,
ZNRF4
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
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目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
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目前还没有研究热点人员