Spsb2 - splA/ryanodine receptor domain and SOCS box containing 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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14794 Spsb2

基因描述

Type	Description
Definition	splA/ryanodine receptor domain and SOCS box containing 2

研究结论

Date	Results	Publications
2020-03-07 10:51:00	these results establish SSB1/2 as safeguards of B cell development and unveil their differential requirement in immature and mature B lymphocytes	31085591
2017-09-02 11:01:00	Collectively, Ssb1 and Ssb2 control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.	28270450
2010-09-27 12:28:00	structural changes limit high-affinity interactions for SPSB2 to aspartate-containing sequences	20561531
2010-08-02 11:31:00	The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation.	20603330
2010-01-21 00:00:00	Determined the first SPRY-domain structure of SSB-2 that adopts a novel fold and contains conserved structural determinants for binding to prostate apoptosis response protein-4 (PAR-4).	16369487

名称对应

Type	IDs
Synonymous	AI461677, C9, Grcc9, SSB2
Gene	UniProtKB-ID: SPSB2_MOUSE UniprotKB: O88838 UniParc: UPI0000029727, UPI0000026906 EMBL: BC002005, BC010305, AK148177, AC002397, AF403037, AK036451 Ensembl: ENSMUSG00000038451 KO: mmu:14794
Nucleutide sequences	EMBL-CDS: AAC36017.1, AAH10305.1, BAE28397.1, AAL57356.1, BAC29435.1, AAH02005.1 Ensembl_TRS: ENSMUST00000112473, ENSMUST00000052727, ENSMUST00000047760
Protein sequencees	Ensembl_PRO: ENSMUSP00000060124, ENSMUSP00000108092, ENSMUSP00000041585 RefSeq: XP_030111032.1, XP_030111031.1, XP_030111033.1, NP_001292979.1, NP_001292980.1, XP_036021748.1, XP_006505629.2, NP_038567.1, NP_001292981.1, NP_001292982.1, XP_006505630.1
Others	UniRef100: UniRef100_O88838 UniRef90: UniRef90_O88838 UniRef50: UniRef50_O88838 UniGene: Mm.261906 CCDS: CCDS20529.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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全选

Pubmed编号	文献信息	发表日期	相关基因
31085591	SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors. J Immunol Matthias Pfeifer , Reto Brem , Timothy P Lippert , Bryant Boulianne , Howin Ng Ho , Mark E Robinson , Justin Stebbing , Niklas Feldhahn	2019-06-15	-
28270450	Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. Blood Wei Shi , Therese Vu , Didier Boucher , Anna Biernacka , Jules Nde , Raj K Pandita , Jasmin Straube , Glen M Boyle , Fares Al-Ejeh , Purba Nag , Jessie Jeffery , Janelle L Harris , Amanda L Bain , Marta Grzelak , Magdalena Skrzypczak , Abhishek Mitra , Norbert Dojer , Nicola Crosetto , Nicole Cloonan , Olivier J Becherel , John Finnie , Jeffrey R Skaar , Carl R Walkley , Tej K Pandita , Maga Rowicka , Krzysztof Ginalski , Steven W Lane , Kum Kum Khanna	2017-05-04	-
25068993	A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent. J. Med. Chem. Beow Keat Yap , Eleanor W W Leung , Hiromasa Yagi , Charles A Galea , Sandeep Chhabra , David K Chalmers , Sandra E Nicholson , Philip E Thompson , Raymond S Norton	2014-08-28	Spsb2
21876038	TLR regulation of SPSB1 controls inducible nitric oxide synthase induction. J. Immunol. Rowena S Lewis , Tatiana B Kolesnik , Zhihe Kuang , Akshay A D'Cruz , Marnie E Blewitt , Seth L Masters , Andrew Low , Tracy Willson , Raymond S Norton , Sandra E Nicholson	2011-10-01	Spsb2, Nos2, Spsb1
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21677750	A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley	2011-06-15	-
20561531	Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. J. Mol. Biol. Panagis Filippakopoulos , Andrew Low , Timothy D Sharpe , Jonas Uppenberg , Shenggen Yao , Zhihe Kuang , Pavel Savitsky , Rowena S Lewis , Sandra E Nicholson , Raymond S Norton , Alex N Bullock	2010-08-20	-
20603330	The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. J Cell Biol Zhihe Kuang , Rowena S Lewis , Joan M Curtis , Yifan Zhan , Bernadette M Saunders , Jeffrey J Babon , Tatiana B Kolesnik , Andrew Low , Seth L Masters , Tracy A Willson , Lukasz Kedzierski , Shenggen Yao , Emanuela Handman , Raymond S Norton , Sandra E Nicholson	2010-07-12	-
19154741	SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding. J. Mol. Biol. Zhihe Kuang , Shenggen Yao , Yibin Xu , Rowena S Lewis , Andrew Low , Seth L Masters , Tracy A Willson , Tatiana B Kolesnik , Sandra E Nicholson , Thomas J P Garrett , Raymond S Norton	2009-02-27	Spsb2
18799693	Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. Gwenn M Hansen , Diane C Markesich , Michael B Burnett , Qichao Zhu , Karen M Dionne , Lizabeth J Richter , Richard H Finnell , Arthur T Sands , Brian P Zambrowicz , Alejandro Abuin	2008-10-01	Gm11335, Gm17762, A930017K11Rik, BC028777, Gm13999, Gm11696, Gm12359, Gm10589, D030047H15Rik, Gm10856, Gm10685, Gm10062, Gm10433, Gm10648, Gm10840, Gm15441, Gm10684, Gm9900, Gm10822, Gm10687, Gm11744, Gm10747, Arih2os, B230344G16Rik, Fmr1os, Tmem51os1, Gm14488, Gm13033, Gm10789, Gm10615, Gm1976, Gm9967, Gm9917, Gm1974, Gm11496, Gm13580, Gm2085, Gm2183, Gm2245, Tbx3os1, Gm12980, Gm2329, Lncenc1, Gm2381, Snhg12, Gm2479, Gm12942, Gm2529, Gm2533, Rpl30-ps7, Rsf1os2, Gm2695, 2810416G20Rik, Rpl30-ps6, Gm2773, Gm2788, Dynlt1f, Gm9793, Gm2885, Gm2920, Gm15506, Gm11627, Gm10518, Gm13496, Gm3134, Gm12827, Gm3143, Gm10144, Ahnak2, Gm3196, Gm13242, Gm3325, Gm13247, Gm10863, Gm13157, 4930522L14Rik, Gm3552, Gm15226, Gm3604, Gm3643, BC005561, Gm3716, 2810410L24Rik, Gm10282, Gm3839, Nhsl2, 4732419C18Rik, Gm3906, Gm3973, Gm4013, Apol7d, Gm12057, Gm10489, Rex2, 1110002L01Rik, Gm4189, Gm4204, 4632428C04Rik, 9130023H24Rik

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