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1474 CST6

1474

CST6

cystatin E/M

protein-coding

Homo sapiens

基因描述

Type Description
Definition cystatin E/M

研究结论

Date Results Publications
2020-02-01 12:06:00 a loss-of-function variant in the human CST6 gene, which causes a novel autosomal recessive hypotrichosis syndrome 30425301
2018-09-22 10:59:00 High CST6 expression is associated with lymph-node metastasis in Triple-Negative Breast Cancer. 29530995
2017-09-30 13:41:00 Data suggest that melanoma cells internalize/absorb cystatin C from culture media, leading to increased intracellular cystatin C levels; cystatin E/M is internalized as well but at modest rate due to down-regulation of cell migration; however, the effect of intracellular cystatin E/M on down-regulation of legumain activity is pronounced. 28630039
2017-05-27 10:48:00 Results provide evidence that cystatin E/M is a tumor suppressor gene which plays an important role in the regulation of NF-kappaB. 27090639
2015-01-24 12:41:00 Low CST6 expression is associated with breast cancer. 24742492

名称对应

Type IDs
Gene
UniProtKB-ID: CYTM_HUMAN
UniprotKB: Q15828
UniParc: UPI00000015F5
EMBL: AY145051, U62800, U81233, BC031334
Ensembl: ENSG00000175315
KO: hsa:1474
Nucleutide sequences
EMBL-CDS: AAB06566.1, AAB61305.1, AAN52757.1, AAH31334.1
Ensembl_TRS: ENST00000312134
Protein sequencees
Ensembl_PRO: ENSP00000311313
RefSeq: NP_001314.1
Others
UniRef100: UniRef100_Q15828
UniRef90: UniRef90_Q15828
UniRef50: UniRef50_Q15828
UniGene: Hs.139389
CCDS: CCDS8126.1

全选

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