| Type | Description |
|---|---|
| Definition | glycoprotein 1b, alpha polypeptide |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:30:00 | Synergic effect of GPIBA and von Willebrand factor in pathogenesis of deep vein thrombosis. | 31902309 |
| 2020-03-21 12:25:00 | Mouse platelets lacking the extracellular domain of GPIbalpha and human platelets treated with GPIbalpha-blocking antibodies display a reduced aggregation response to synthetic glycopolymers. We found that synthetic sulfated glycopolymers bind directly to GPIbalpha, substantiating that GPIbalpha facilitates the interaction of synthetic glycopolymers with CLEC-2 or PEAR1. | 30700416 |
| 2019-12-21 12:21:00 | Platelet protein disulfide isomerase-facilitated cleavage of the allosteric disulfide bonds tightly regulates GPIbalpha function, promoting platelet-neutrophil interactions, vascular occlusion, and tissue damage under thromboinflammatory conditions. | 30586735 |
| 2019-07-20 11:50:00 | A 2- to 3-fold decrease occurred in circulating TPO in GPIbalpha(-/-) mice compared with wild-type. Lower TPO levels in GPIbalpha-/- mice are due to impaired platelet-stimulated hepatic TPO production. The N terminus of GPIbalpha is required for platelet-mediated hepatic TPO generation. | 29794068 |
| 2018-11-24 12:31:00 | leukocyte Mac-1 and platelet GPIbalpha are involved in thrombosis | 28555620 |
| Type | IDs |
|---|---|
| Synonymous | GP-Ib alpha, GPIba, GPIbalpha |
| Gene |
UniProtKB-ID:
GP1BA_MOUSE,
A2CFB8_MOUSE
UniprotKB:
O35930,
A2CFB8
UniParc:
UPI0000194FB0
EMBL:
U91967,
BC137765,
AL596117
Ensembl:
ENSMUSG00000050675
KO:
mmu:14723
|
| Nucleutide sequences |
EMBL-CDS:
AAC53320.1,
AAI37766.1
Ensembl_TRS:
ENSMUST00000108551,
ENSMUST00000055184
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000057563,
ENSMUSP00000104191
RefSeq:
NP_034456.2,
XP_006532295.1
|
| Others |
UniRef100:
UniRef100_O35930
UniRef90:
UniRef90_O35930
UniRef50:
UniRef50_P07359
UniGene:
Mm.377085
CCDS:
CCDS24957.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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