| Type | Description |
|---|---|
| Definition | notum, palmitoleoyl-protein carboxylesterase |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 12:57:00 | Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. | 31876313 |
| 2020-05-30 13:47:00 | Therapies targeting osteoblast-derived NOTUM may prevent nonvertebral fractures. | 31307226 |
| 2019-10-12 12:42:00 | results reveal a role of the stem cell niche in ageing and demonstrate that targeting of Notum can promote regeneration of aged tissues | 31292548 |
| 2018-12-22 12:01:00 | NOTUM expression was increased in metastatic cells. Proliferation was suppressed by inhibiting expression of NOTUM. Knockdown of NOTUM genes inhibited proliferation as well as migration, with possible involvement of p38 and c-JUN N-terminal kinase in this process. | 30343282 |
| 2016-10-01 11:18:00 | Data show that notum and glypican-1 and glypican-3 gene expression during colorectal cancer (CRC) development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis. | 26517809 |
| Type | IDs |
|---|---|
| Synonymous | hNOTUM |
| Gene |
UniProtKB-ID:
NOTUM_HUMAN
UniprotKB:
Q6P988
UniParc:
UPI000004EE80
EMBL:
AB062438,
AC145207,
BC060882,
BC036872
Ensembl:
ENSG00000185269
KO:
hsa:147111
|
| Nucleutide sequences |
EMBL-CDS:
BAB93501.1,
AAH60882.1,
AAH36872.2
Gene_ORFName:
OK/SW-CL.30
Ensembl_TRS:
ENST00000409678
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000387310
RefSeq:
NP_848588.3
|
| Others |
UniRef100:
UniRef100_Q6P988
UniRef90:
UniRef90_Q6P988
UniRef50:
UniRef50_Q6P988
UniGene:
Hs.106137
CCDS:
CCDS32771.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 31876313 |
Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. J Pineal Res Yuguang Zhao , Jingshan Ren , James Hillier , Margaret Jones , Weixian Lu , Edith Yvonne Jones |
2020-03-01 | - |
| 31307226 |
FASEB J. Sofia Movérare-Skrtic , Karin H Nilsson , Petra Henning , Thomas Funck-Brentano , Maria Nethander , Fernando Rivadeneira , Glaucia Coletto Nunes , Antti Koskela , Juha Tuukkanen , Jan Tuckermann , Christine Perret , Pedro Paulo Chaves Souza , Ulf H Lerner , Claes Ohlsson |
2019-10-01 | - |
| 31292548 |
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. Nature Nalle Pentinmikko , Sharif Iqbal , Miyeko Mana , Simon Andersson , Armand B Cognetta , Radu M Suciu , Jatin Roper , Kalle Luopajärvi , Eino Markelin , Swetha Gopalakrishnan , Olli-Pekka Smolander , Santiago Naranjo , Tuure Saarinen , Anne Juuti , Kirsi Pietiläinen , Petri Auvinen , Ari Ristimäki , Nitin Gupta , Tuomas Tammela , Tyler Jacks , David M Sabatini , Benjamin F Cravatt , Ãmer H Yilmaz , Pekka Katajisto |
2019-07-01 | - |
| 26517809 |
Novel insights into Notum and glypicans regulation in colorectal cancer. Oncotarget Mariangela De Robertis , Maddalena Arigoni , Luisa Loiacono , Federica Riccardo , Raffaele Adolfo Calogero , Yana Feodorova , Dessislava Tashkova , Vesselin Belovejdov , Victoria Sarafian , Federica Cavallo , Emanuela Signori |
2015-12-01 | - |
| 25731175 |
Notum deacylates Wnt proteins to suppress signalling activity. Nature Satoshi Kakugawa , Paul F Langton , Matthias Zebisch , Steve Howell , Tao-Hsin Chang , Yan Liu , Ten Feizi , Ganka Bineva , Nicola O'Reilly , Ambrosius P Snijders , E Yvonne Jones , Jean-Paul Vincent |
2015-03-12 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 18429952 |
Cancer Sci. Yuichi Torisu , Akira Watanabe , Aya Nonaka , Yutaka Midorikawa , Masatoshi Makuuchi , Takahiro Shimamura , Haruhiko Sugimura , Atsushi Niida , Tetsu Akiyama , Hiroko Iwanari , Tatsuhiko Kodama , Mikio Zeniya , Hiroyuki Aburatani |
2008-06-01 |
Notum,
Notum,
NOTUM
|
| 17207965 |
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics Philippe Lamesch , Ning Li , Stuart Milstein , Changyu Fan , Tong Hao , Gabor Szabo , Zhenjun Hu , Kavitha Venkatesan , Graeme Bethel , Paul Martin , Jane Rogers , Stephanie Lawlor , Stuart McLaren , Amélie Dricot , Heather Borick , Michael E Cusick , Jean Vandenhaute , Ian Dunham , David E Hill , Marc Vidal |
2007-03-01 |
GNPDA1,
CTAGE4,
BCL2L11,
PIGK,
TIMM23,
NPIPA5,
CST8,
AP1M2,
COX17,
TIMM23B,
SNX29P1,
IL18BP,
RWDD2B,
TSSC4,
UPK1A-AS1,
ARPC5,
ARPC3,
TSPAN5,
TSPAN3,
TSPAN1,
PPIF,
CTDSP2,
NAMPT,
PDZK1IP1,
DHRS9,
RBM7,
MPHOSPH6,
DHRS2,
MPZL2,
GPA33,
CALCOCO2,
SPRY3,
SPRY1,
RAMP3,
TRAIP,
DNAJA2,
IKZF1,
CRISP3,
SIRPB1,
CNPY2,
B3GNT3,
WARS2,
NPM3,
CDO1,
CACNG3,
TUBB4B,
CEPT1,
PEMT,
WFDC2,
NSA2,
EMG1,
TIMM17A,
PPIE,
HAX1,
CIB2,
DCTN2,
RPP38,
SLC35A1,
IFI44,
CXCL13,
SIVA1,
MRPL28,
CENPA,
MAB21L2,
RAD51AP1,
MTX2,
CGRRF1,
DCTN6,
B3GNT2,
CLDN16,
PNMA2,
KLRA1P,
SRSF10,
ARPP21,
STARD10,
CGA,
EDDM3A,
CFHR3,
GPR83,
RAB10,
CPSF4,
RUNDC3A,
COPS8,
C11orf58,
CCDC85B,
GLIPR1,
KLK11,
SNRNP27,
LIAS,
LILRA2,
SNRNP35,
CYB561D2,
ESM1,
WDR5,
BTN2A1,
HHLA3,
BVES,
KLK8,
MRPL3
|
| 12477932 |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team |
2002-12-24 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员