| Type | Description |
|---|---|
| Definition | Berardinelli-Seip congenital lipodystrophy 2 (seipin) |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:14:00 | Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy. | 31848133 |
| 2020-09-26 13:03:00 | Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy. | 31185001 |
| 2020-01-18 12:59:00 | the effects of SEIPIN on triglyceride and PGC-1alpha are dependent on calcium concentrations, signifying regulatory activity on hepatic lipometabolism through alterations in the intracellular calcium level. | 30871963 |
| 2020-01-11 11:26:00 | neuronal seipin deletion causes hyperphosphorylation and aggregation of tau protein leading to axonal atrophy through reduced PPARgamma to enhance GSK3beta and Akt/mTOR signaling; systemic seipin deletion-induced insulin resistance causes tau hyperphosphorylation via cascading JNK pathway. | 30910747 |
| 2019-11-16 12:44:00 | Study links BSCL2 lipodystrophy to reduced triglycerides but excess glycogen in hypertrophic skeletal muscle. Incomplete fatty acid oxidation in muscle of Bscl2-/- mice results in insulin resistance, while hyperinsulinemia may trigger excessive muscle glycogen synthesis and growth. Also, circulating fatty acids level in BSCL2 lipodystrophy are a key determinant of oxidative muscle insulin sensitivity and glucose uptake. | 30521848 |
| Type | IDs |
|---|---|
| Synonymous | 2900097C17Rik, AI046355, Gng3lg |
| Gene |
UniProtKB-ID:
BSCL2_MOUSE,
A0A0R4J225_MOUSE
UniprotKB:
Q9Z2E9,
A0A0R4J225
UniParc:
UPI0000020D7B,
UPI000000B2CA
EMBL:
BC043023,
BC061689,
AF069954,
AK158901,
AC129217,
AB030196,
AK151606,
AK155753,
AK170183,
AB041588
Ensembl:
ENSMUSG00000071657
KO:
mmu:14705
|
| Nucleutide sequences |
EMBL-CDS:
AAH61689.1,
BAA95071.1,
AAH43023.2,
BAE34722.1,
AAC77923.2,
BAE30545.1,
BAE41621.1,
BAE33418.1,
BAA92759.1
Gene_ORFName:
MNCb-2630
Ensembl_TRS:
ENSMUST00000086058,
ENSMUST00000160556,
ENSMUST00000159634,
ENSMUST00000171649
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000083224,
ENSMUSP00000125422,
ENSMUSP00000123976,
ENSMUSP00000127685
RefSeq:
XP_006526754.1,
XP_030106614.1,
NP_001277752.1,
NP_032170.3,
NP_001129536.1
|
| Others |
UniRef100:
UniRef100_Q9Z2E9
UniRef90:
UniRef90_Q9Z2E9
UniRef50:
UniRef50_Q96G97
UniGene:
Mm.345134
CCDS:
CCDS70931.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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