| Type | Description |
|---|---|
| Definition | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:28:00 | Gqalpha/G11alpha deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity. | 33166186 |
| 2021-02-20 13:31:00 | Gs/Gq signaling switch in beta cells defines incretin effectiveness in diabetes. | 33196462 |
| 2020-06-20 12:49:00 | depleted GNAS exerts an inhibitory role in osteogenic differentiation of mesenchymal stem cells by activating Hippo signaling pathway. | 31148202 |
| 2020-02-15 10:28:00 | Findings suggest that guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (XLalphas) ablation does not substantially alter fibroblast growth factor-23 (FGF23) production in adult mice but increases susceptibility to adenine-induced kidney injury, causing severe FGF23 elevations in plasma and bone. | 31758181 |
| 2019-09-07 11:55:00 | Gsalpha signaling in osteocytes leads to osteopenia driven, at least in part, by increased secretion of sclerostin. | 30266511 |
| Type | IDs |
|---|---|
| Synonymous | 5530400H20Rik, A930027G11Rik, C130027O20Rik, GPSA, GSP, Galphas, Gnas1, Gnasxl, Gs-alpha, Gsa, Nesp, Nesp55, Nespl, Oed-Sml, Oedsml, P1, P2, P3, PHP1A, PHP1B, POH, SCG6 |
| Gene |
UniProtKB-ID:
ALEX_MOUSE,
GNAS1_MOUSE,
GNAS2_MOUSE,
GNAS3_MOUSE,
A0A571BEI3_MOUSE
UniprotKB:
Q6R0H6,
Q6R0H7,
P63094,
Q9Z0F1,
A0A571BEI3
UniParc:
UPI000023B627,
UPI000021343A,
UPI0000022C19,
UPI00000E7F89,
UPI0000485A74,
UPI0000DBED2F,
UPI0000E444AF,
UPI0000001ACB,
UPI000023B625,
UPI000023B628,
UPI000023B626
EMBL:
AK030489,
AK159563,
AJ010163,
AY518306,
AY518305,
AF175305,
AY518307,
BC038067,
AJ245401,
AK168996,
AY519502,
BC048834,
AB041808,
BC061496,
AY519504,
AF107848,
AY519501,
BC092055,
AF107847,
BC106133,
AY519503,
AL593857,
AJ251761,
BC080816,
AF116268,
AK147051,
BC062654,
M13964,
Y00703,
AK039035,
AY518308
Ensembl:
ENSMUSG00000027523
KO:
mmu:14683
|
| Nucleutide sequences |
EMBL-CDS:
AAS00602.1,
BAC26987.1,
AAR99383.1,
AAS00601.1,
AAR99380.1,
AAR99381.1,
AAR99382.1,
AAD14686.1,
AAS00603.1,
CAB83219.1,
AAS00604.1,
AAH92055.1,
AAA37745.1,
AAH38067.1,
BAE40795.1,
AAH62654.1,
BAE35187.1,
BAE27636.1,
AAI06134.1,
CAM24410.1,
AAD11807.1,
AAH48834.1,
CAM24411.1,
AAH61496.1,
CAA68695.1,
AAH80816.1,
CAM24412.1,
BAB93551.1,
CAB57280.1,
BAC30214.1,
CAB83218.1,
AAD11806.1,
AAD55061.1,
CAA09026.1,
AAD11805.1
Gene_ORFName:
MNCb-5546
Ensembl_TRS:
ENSMUST00000109088,
ENSMUST00000186907,
ENSMUST00000080493,
ENSMUST00000087877,
ENSMUST00000185956,
ENSMUST00000154658,
ENSMUST00000087876,
ENSMUST00000087871,
ENSMUST00000109087,
ENSMUST00000109085,
ENSMUST00000109096,
ENSMUST00000180362,
ENSMUST00000109095,
ENSMUST00000156623
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000139839,
ENSMUSP00000104716,
ENSMUSP00000079341,
ENSMUSP00000085185,
ENSMUSP00000158758,
ENSMUSP00000085184,
ENSMUSP00000140174,
ENSMUSP00000085179,
ENSMUSP00000104715,
ENSMUSP00000104713,
ENSMUSP00000104724,
ENSMUSP00000136180,
ENSMUSP00000104723,
ENSMUSP00000158707
RefSeq:
XP_006498840.1,
XP_006498841.1,
NP_001070978.1,
NP_963911.1,
NP_001350959.1,
NP_001297014.1,
NP_963912.1,
NP_963910.1,
NP_001297012.1,
NP_068840.2,
XP_006498843.1,
NP_001070975.1,
NP_034439.2,
XP_006498837.1,
XP_017171147.1,
XP_030103428.1,
XP_030103429.1,
NP_062664.2
|
| Others |
UniRef100:
UniRef100_A0A571BEI3,
UniRef100_Q9Z0F1,
UniRef100_P63094,
UniRef100_Q6R0H6,
UniRef100_Q6R0H7
UniRef90:
UniRef90_Q6R0H6,
UniRef90_A0A571BEI3,
UniRef90_P63092-2,
UniRef90_Q6R0H7,
UniRef90_Q9Z0F1
UniRef50:
UniRef50_Q9Z213,
UniRef50_Q63803,
UniRef50_Q792G6,
UniRef50_P63092-2
UniGene:
Mm.125770,
Mm.394046
CCDS:
CCDS50817.1,
CCDS17151.1,
CCDS38355.1,
CCDS38354.1,
CCDS89590.1,
CCDS38356.1,
CCDS38357.1,
CCDS17149.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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