| Type | Description |
|---|---|
| Definition | guanine nucleotide binding protein, alpha 12 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-01 11:07:00 | Here, the authors show that small arteries from mice with smooth muscle-specific loss of G12/G13 or the Rho guanine nucleotide exchange factor ARHGEF12 have lost myogenic vasoconstriction. | 31549965 |
| 2019-09-21 10:54:00 | results demonstrate that Galpha12 regulates SIRT1-dependent mitochondrial respiration through HIF-1alpha-dependent USP22 induction, identifying Galpha12 as an upstream molecule that contributes to the regulation of mitochondrial energy expenditure. | 30300140 |
| 2019-06-29 11:10:00 | The results of this study suggest that a balance in the expression of Go1alpha and Go2alpha sustains normal motor function. Deletion of either splice variant results in divergent behavioural and molecular alterations in the striatal dopaminergic system. | 29747224 |
| 2019-04-27 10:32:00 | Galpha12 plays a role in differentiation through NFATc1 and in cell migration and resorption activity through RhoA during osteoclastogenesis. | 29077264 |
| 2017-08-05 11:54:00 | Galpha12 is required for the development of kidney cysts induced by Pkd1 mutation in mouse autosomal dominant polycystic kidney disease. | 27505895 |
| Type | IDs |
|---|---|
| Synonymous | AI414047, AI504261, Galpha12 |
| Gene |
UniProtKB-ID:
GNA12_MOUSE
UniprotKB:
P27600
UniParc:
UPI0000020A5F
EMBL:
M63659,
M57618
Ensembl:
ENSMUSG00000000149
KO:
mmu:14673
|
| Nucleutide sequences |
EMBL-CDS:
AAA37648.1,
AAA63302.1
Ensembl_TRS:
ENSMUST00000000153
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000000153
RefSeq:
NP_034432.1
|
| Others |
UniRef100:
UniRef100_P27600
UniRef90:
UniRef90_P27600
UniRef50:
UniRef50_P27600
UniGene:
Mm.370185
CCDS:
CCDS19825.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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