| Type | Description |
|---|---|
| Definition | guanine nucleotide binding protein, alpha 11 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:55:00 | The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects. | 32576659 |
| 2019-06-29 11:10:00 | This study demonstrated that balance in the expression of Go1alpha and Go2alpha sustains normal motor function. Deletion of either splice variant results in divergent behavioural and molecular alterations in the striatal dopaminergic system. | 29747224 |
| 2019-06-22 12:06:00 | RasGRP3 is specifically required for GNAQ/GNA11-driven Ras activation and tumorigenesis. | 29490280 |
| 2019-06-22 10:41:00 | Study has revealed Dsk7 mice harboring a germline hypermorphic Galpha11 mutation, Ile62Val, to have hypocalcemia and reduced PTH concentrations, which are caused by a gain-of-function Gna11 mutation that leads to upregulation of CaSR-mediated Ca2+ and MAPK signaling responses. | 28194447 |
| 2019-06-22 10:41:00 | GNA11R60C mutant knockin mice mimic the human autosomal-dominant hypocalcemia type 2 (ADH2) disease, with hypocalcemia and inappropriately low PTH levels demonstrating that this mutation is sufficient to cause ADH2. | 28194446 |
| Type | IDs |
|---|---|
| Synonymous | Dsk7, E430025L19, g alpha-11 |
| Gene |
UniProtKB-ID:
GNA11_MOUSE,
Q3UPA1_MOUSE
UniprotKB:
P21278,
Q3UPA1
UniParc:
UPI00000259D5
EMBL:
U37412,
M55411,
U37413,
U37411,
M57617,
AK143685
Ensembl:
ENSMUSG00000034781
KO:
mmu:14672
|
| Nucleutide sequences |
EMBL-CDS:
AAB36839.1,
AAA63301.1,
AAA63305.1,
BAE25496.1
Ensembl_TRS:
ENSMUST00000043604
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000043190
RefSeq:
NP_034431.1
|
| Others |
UniRef100:
UniRef100_P21278
UniRef90:
UniRef90_P29992
UniRef50:
UniRef50_P29992
UniGene:
Mm.260925,
Mm.471081
CCDS:
CCDS24061.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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