| Type | Description |
|---|---|
| Definition | glutamate-ammonia ligase (glutamine synthetase) |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 12:43:00 | Gln synthetase (GS) activity and expression significantly increase from postnatal day 7 to 21 in newborn mice and GS is expressed prior to GFAP and is more abundant than GFAP throughout synaptogenesis. Inhibiting GS activity in neonatal mice resulted in spatial memory-related impairment in adults. Results suggest that postnatal GS activity is important for glutamatergic synapse development in CA3. | 30670758 |
| 2018-12-22 10:31:00 | genetic deletion of Glul in endothelial cells impairs vessel sprouting during vascular development, whereas pharmacological blockade of glutamine synthetase suppresses angiogenesis in ocular and inflammatory skin disease while only minimally affecting healthy adult quiescent endothelial cells | 30158707 |
| 2018-04-28 11:18:00 | The data identify GS activity as mediator of the proangiogenic, immunosuppressive, and pro-metastatic function of M2-like macrophages and highlight the possibility of targeting this enzyme in the treatment of cancer metastasis. | 28813676 |
| 2017-08-12 10:06:00 | Our study highlights a new role of GS in modulating immune response in microglia, providing insights into the pathogenic mechanisms associated with inflammation and new strategies of therapeutic intervention | 27758118 |
| 2017-07-08 10:13:00 | We conclude that 1) GS-mediated ammonia recycling in the PT contributes to both basal and acidosis-stimulated ammonia metabolism and 2) adaptive changes in other proteins involved in ammonia metabolism occur in response to PT-GS-KO and cause an underestimation of the role of PT GS expression. | 27009341 |
| Type | IDs |
|---|---|
| Synonymous | GS, Glns |
| Gene |
UniProtKB-ID:
GLNA_MOUSE
UniprotKB:
P15105
UniParc:
UPI00000E71E6
EMBL:
AK160670,
BC015086,
AK168493,
AK159106,
AK162685,
U09114,
AY044241,
X16314
Ensembl:
ENSMUSG00000026473
KO:
mmu:14645
|
| Nucleutide sequences |
EMBL-CDS:
BAE37022.1,
BAE40380.1,
BAE35950.1,
AAK95328.1,
AAH15086.1,
BAE34822.1,
AAA17989.1,
CAA34381.1
Ensembl_TRS:
ENSMUST00000086199,
ENSMUST00000140685
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000083375,
ENSMUSP00000123157
RefSeq:
NP_032157.2
|
| Others |
UniRef100:
UniRef100_P15105
UniRef90:
UniRef90_P15105
UniRef50:
UniRef50_P09606
UniGene:
Mm.210745
CCDS:
CCDS15381.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员