| Type | Description |
|---|---|
| Definition | glutamate-cysteine ligase, modifier subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-04-10 17:50:00 | The development of glutamate cysteine ligase [GCL] transgenic and gene deletion mouse lines are described. | 23045016 |
| 2017-02-04 11:21:00 | glutathione levels in the skin of Gclm knock-out mice are reduced by 70 %, which is sufficient for wound repair in young mice, but become rate-limiting upon aging | 27262586 |
| 2015-11-21 10:48:00 | Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress. | 26083875 |
| 2015-01-03 10:42:00 | Upregulation of both GCLC and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis. | 24557597 |
| 2014-05-03 11:18:00 | In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin interneurons and have long-term consequences. | 23140664 |
| Type | IDs |
|---|---|
| Synonymous | AI649393, Gcmc, Glclr |
| Gene |
UniProtKB-ID:
GSH0_MOUSE,
Q4FJZ6_MOUSE
UniprotKB:
O09172,
Q4FJZ6
UniParc:
UPI0000003F60
EMBL:
BC132404,
AF149056,
BC138783,
AF149057,
AF149060,
CT010256,
AF149055,
U95053,
AF149059,
AF149058,
AF149054,
AK028236
Ensembl:
ENSMUSG00000028124
KO:
mmu:14630
|
| Nucleutide sequences |
EMBL-CDS:
AAB96893.1,
AAG15424.1,
BAC25831.1,
CAJ18464.1,
AAI38784.1,
AAI32405.1
Ensembl_TRS:
ENSMUST00000178826,
ENSMUST00000029769
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000029769,
ENSMUSP00000136987
RefSeq:
NP_032155.1
|
| Others |
UniRef100:
UniRef100_O09172
UniRef90:
UniRef90_P48508
UniRef50:
UniRef50_P48508
UniGene:
Mm.292676
CCDS:
CCDS17808.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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