| Type | Description |
|---|---|
| Definition | glutamate-cysteine ligase, catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-04-10 17:50:00 | The development of glutamate cysteine ligase [GCL] transgenic and gene deletion mouse lines are described. | 23045016 |
| 2018-04-14 10:24:00 | The findings indicate that expression of the transcription factor NRF2 and its effector GCL are both profoundly deregulated in endometriotic lesions towards increased growth and fibrogenetic processes. | 28457937 |
| 2018-01-13 12:52:00 | Retinal GCLC was significantly increased in rd10 mice at P21 as well as GSSG. Our results suggest alterations in retinal GCLC content and GSH and/or its precursors in these two RP animal models. Regulation of the enzymes related to GSH metabolism and the retinal concentration of glutamate may be a possible target to delay especially cone death in Retinitis Pigmentosa | 27140233 |
| 2017-06-03 11:28:00 | Data show that the catalytic subunit of glutamate cysteine ligase (Gclc)-derived glutathione buffers reactive oxygen species and regulates metabolic reprogramming. | 28423341 |
| 2017-05-20 12:11:00 | To study the biological effects of low GSH levels, we disrupted its synthesis both at birth by breeding a Gclc loxP mouse with a thy1-cre mouse and at a later age by breeding with a CaMKII-ERT2-Cre (FIGSKO mouse). FIGSKO mice also develop cognitive abnormalities, i.e. learning impairment and nesting behaviors based on passive avoidance, T-Maze, and nesting behavior tests | 28158580 |
| Type | IDs |
|---|---|
| Synonymous | D9Wsu168e, GLCL-H, Ggcs-hs, Glclc |
| Gene |
UniProtKB-ID:
GSH1_MOUSE,
Q3TEF1_MOUSE,
Q3UNA7_MOUSE
UniprotKB:
P97494,
Q3TEF1,
Q3UNA7
UniParc:
UPI00005AC2D8,
UPI000016D156
EMBL:
U85414,
AK169676,
AK160876,
BC019374,
AK144339,
U85498
Ensembl:
ENSMUSG00000032350
KO:
mmu:14629
|
| Nucleutide sequences |
EMBL-CDS:
AAB42020.1,
AAH19374.1,
AAB52542.1,
BAE36064.1,
BAE41297.1,
BAE25840.1
Ensembl_TRS:
ENSMUST00000034905
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000034905
RefSeq:
XP_006510875.1,
NP_034425.1
|
| Others |
UniRef100:
UniRef100_Q3UNA7,
UniRef100_P97494
UniRef90:
UniRef90_P19468,
UniRef90_P97494
UniRef50:
UniRef50_P19468
UniGene:
Mm.89888
CCDS:
CCDS23354.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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