| Type | Description |
|---|---|
| Definition | polymerase Pb2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-04 11:31:00 | investigated the evolutionary dynamics of H9N2 in the Middle East and identified phylogeny-associated PB2 mutations that acted cooperatively to increase H9N2 replication/transcription in human cells | 31265471 |
| 2019-03-09 10:56:00 | Our results supported that the D253N mutation in the middle domain of PB2, similar to mutations at the 627 and NLS domains, specifically contributed to the replication of avian influenza viruses in human cells. | 30569291 |
| 2017-12-16 11:09:00 | findings demonstrate that a single point mutation in the PB2 of a low pathogenic H9N2 isolate could have a significant effect on viral phenotype and increase its propensity to infect mammals | 27101787 |
| 2016-06-11 11:41:00 | PB2 nuclear localisation signal (NLS)enhances the viral ribonucleoprotein present in the nucleus suggesting entry of viral ribonucleoproteins into the nucleus depends on controlled interplay of NLSs of PB2 and nucleoprotein with nuclear import machinery. | 26074198 |
| 2016-03-26 11:56:00 | H9N2 avian influenza virus PB2 E627K mutation contributed to a set of differentially expressed lung proteins, including proteins that are chiefly involved within the cytoskeleton and motor proteins, antiviral proteins, regulation of glucocorticoids signal-associated proteins, pro- and anti-inflammatory proteins. | 25641917 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
Q9ICY1_9INFA
UniprotKB:
Q9ICY1
UniParc:
UPI00000F80C1
EMBL:
AJ404630
KO:
vg:1460998
|
| Nucleutide sequences |
EMBL-CDS:
CAB95860.1
|
| Protein sequencees |
RefSeq:
NP_859039.1
|
| Others |
UniRef100:
UniRef100_Q9ICY1
UniRef90:
UniRef90_P03427
UniRef50:
UniRef50_P03427
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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