| Type | Description |
|---|---|
| Definition | growth hormone receptor |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 10:46:00 | Loss of growth hormone-mediated signal transducer and activator of transcription 5 signaling in mice results in insulin sensitivity with obesity. | 30779881 |
| 2020-02-01 11:21:00 | Adipocyte-specific GH knockout receptor mice have an increase in adipocyte size and white adipose tissue depot mass. | 30462209 |
| 2019-04-20 10:48:00 | Chow-fed, adult-onset, hepatocyte-specific, GH receptor knockdown (aHepGHRkd) mice rapidly (within 7 days) develop steatosis associated with increased hepatic de novo lipogenesis, independent of changes in systemic metabolic function. 6 months after induction of aHepGHRkd early signs of NASH develop, which include hepatocyte ballooning, inflammation, signs of mild fibrosis, and elevated plasma alanine aminotransferase. | 30295789 |
| 2018-01-27 12:07:00 | GHR -/- mice had decreased body weight but increased percent fat mass. Serum FGF21 levels were unchanged in GHR -/- mice. Expression of Fgf21, Fgfr1, and Klb mRNA in white AT and liver were downregulated or unchanged inGHR -/- mice. The only exception was Fgf21 expression in brown AT of GHR -/-, which trended toward increased expression. | 27585733 |
| 2017-10-14 12:50:00 | A role for GH in influencing hormone signaling in adipose tissue in a depot-dependent manner in GHR-/- knock-out mice. | 28323915 |
| Type | IDs |
|---|---|
| Synonymous | GHBP, GHR/BP |
| Gene |
UniProtKB-ID:
GHR_MOUSE,
Q3UP14_MOUSE,
Q3UNY8_MOUSE
UniprotKB:
P16882,
Q3UP14,
Q3UNY8
UniParc:
UPI00005AC259,
UPI00000E7740,
UPI0000027169,
UPI0000021E2C
EMBL:
U49266,
AF120484,
AK143925,
M33324,
BC075720,
U49268,
AY271378,
AK143886,
AC161799,
AF120488,
U49267,
AC113323,
AF120483,
AF120482,
U15011,
AF120487,
AF120481,
M31680,
AF120485,
AF120486,
AC166491,
U15013,
BC024375,
AC121307,
AF120489,
U43933,
U15012
Ensembl:
ENSMUSG00000055737
KO:
mmu:14600
|
| Nucleutide sequences |
EMBL-CDS:
AAD32556.1,
AAA69000.1,
AAK62803.1,
AAP33018.1,
AAA37689.1,
AAK62802.1,
AAA37690.1,
AAH24375.1,
AAH75720.1,
AAD32555.1,
BAE25583.1,
BAE25609.1
Ensembl_TRS:
ENSMUST00000110697,
ENSMUST00000110698,
ENSMUST00000161561,
ENSMUST00000069451
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000106326,
ENSMUSP00000106325,
ENSMUSP00000069457,
ENSMUSP00000124064
RefSeq:
NP_001041643.1,
NP_001273299.1,
NP_034414.2
|
| Others |
UniRef100:
UniRef100_Q3UP14,
UniRef100_P16882,
UniRef100_Q3UNY8
UniRef90:
UniRef90_P16882
UniRef50:
UniRef50_P16310
UniGene:
Mm.3986
CCDS:
CCDS27358.1,
CCDS37024.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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