| Type | Description |
|---|---|
| Definition | geranylgeranyl diphosphate synthase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:19:00 | The expression level of geranylgeranyl diphosphate synthase (Ggpps), is lower in Non-obstructive azoospermia (NOA) patients than that in obstructive azoospermia (OA) patients. After Ggpps deletion specifically in Sertoli cells (SCs), the mice are infertile and the phenotype of the SC-Ggpps(-/-) mice is similar to the NOA patients, where the blood-testis barrier and the SC-germ cells adhesions are severely destroyed. | 31171774 |
| 2020-04-18 10:22:00 | The GGPPS deficiency activated lung fibroblast by facilitating transforming growth factor beta1 while antagonizing bone morphogenetic protein 4 signaling. The GGPPS provides protection against pulmonary fibrosis and that the restoration of protein geranylgeranylation may benefit statin-induced lung injury. | 31120854 |
| 2019-08-17 10:04:00 | Geranylgeranyl pyrophosphate synthase mediated protein geranylgeranylation plays an indispensable role in the ventricular chamber maturation and acts as a stage-specific signal to regulate the establishment of cardiac cytoarchitecture during mid-gestation. | 29444209 |
| 2018-07-07 12:17:00 | Ggpps deletion enhanced Rheb farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation | 27374985 |
| 2018-05-05 10:45:00 | the specific deletion of Ggps1, using the Collagen 2-CreER(T2) mice, will accelerate the fracture healing process by activating the Bmp2/Smad-dependent Runx2 pathway. | 28357594 |
| Type | IDs |
|---|---|
| Synonymous | 1810026C22Rik, 9530089B04Rik, AI843169, C79210 |
| Gene |
UniProtKB-ID:
GGPPS_MOUSE,
Q3V0T8_MOUSE,
Q9CZZ6_MOUSE
UniprotKB:
Q9WTN0,
Q3V0T8,
Q9CZZ6
UniParc:
UPI00000E6849,
UPI0000021B89
EMBL:
AK011980,
AK132907,
BC069913,
AB016044,
BC006798,
CT025604
Ensembl:
ENSMUSG00000021302
KO:
mmu:14593
|
| Nucleutide sequences |
EMBL-CDS:
AAH69913.1,
BAA76512.1,
BAE21415.1,
BAB27955.1,
AAH06798.1
Ensembl_TRS:
ENSMUST00000170957,
ENSMUST00000222164,
ENSMUST00000222747
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000126603,
ENSMUSP00000152789,
ENSMUSP00000152428
RefSeq:
XP_017170877.1,
XP_006516612.1,
NP_001318107.1,
XP_036013745.1,
NP_001318048.1,
XP_030103015.1,
NP_001318105.1,
XP_036013744.1,
XP_036013742.1,
XP_036013743.1,
XP_030103013.1,
NP_034412.1,
XP_017170876.1,
XP_017170874.1,
NP_001318106.1,
XP_036013746.1,
NP_001318109.1,
XP_011242583.1
|
| Others |
UniRef100:
UniRef100_Q9CZZ6,
UniRef100_Q9WTN0
UniRef90:
UniRef90_Q9CZZ6,
UniRef90_O95749
UniRef50:
UniRef50_O95749,
UniRef50_A0A6J8ASJ9
UniGene:
Mm.148039
CCDS:
CCDS26248.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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