| Type | Description |
|---|---|
| Definition | growth differentiation factor 9 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-09 12:44:00 | GDF9 + BMP15, but not separately, significantly induce AMH expression in vitro and in vivo. GDF9 + BMP15, through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of H3K27ac, facilitating AMH expression. | 30060157 |
| 2017-03-04 11:12:00 | Data show that Rac1 induced nuclear import of by physical binding, and nuclear duanyu18133 directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 and BMP15. | 27050391 |
| 2016-03-19 10:44:00 | In organogenesis of the ovary, production of Dhh/Ihh in granulosa cells requires growth differentiation factor 9 from the oocyte. | 25917826 |
| 2015-12-19 10:10:00 | results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals. | 26254468 |
| 2015-08-29 10:31:00 | The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity during heterodimer formation. | 25253739 |
| Type | IDs |
|---|---|
| Synonymous | Gdf-9 |
| Gene |
UniProtKB-ID:
GDF9_MOUSE,
Q7TPZ4_MOUSE,
Q3UWR9_MOUSE
UniprotKB:
Q07105,
Q7TPZ4,
Q3UWR9
UniParc:
UPI000019B082,
UPI000002159A
EMBL:
AK136145,
L06444,
BC052667,
X77113,
X77112
Ensembl:
ENSMUSG00000018238
KO:
mmu:14566
|
| Nucleutide sequences |
EMBL-CDS:
AAA53035.1,
AAH52667.1,
BAE22845.1
Ensembl_TRS:
ENSMUST00000018382
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000018382
RefSeq:
XP_006532283.1,
XP_006532284.1,
XP_030101430.1,
NP_032136.2
|
| Others |
UniRef100:
UniRef100_Q7TPZ4,
UniRef100_Q07105
UniRef90:
UniRef90_Q07105
UniRef50:
UniRef50_Q07105
UniGene:
Mm.9714,
Mm.490461
CCDS:
CCDS24679.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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