| Type | Description |
|---|---|
| Definition | growth differentiation factor 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:59:00 | GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype. | 31947892 |
| 2018-09-08 10:47:00 | Data, including data from studies using knockout mice, suggest that Gdf3-Alk7 axis between adipose tissue macrophages and adipocytes represents previously unrecognized mechanism by which insulin regulates both fat metabolism/lipolysis and adiposity. (Gdf3 = growth differentiation factor-3; Alk7 = activin receptor-like kinase-7) | 29945891 |
| 2017-09-16 11:52:00 | This work establishes PPARgamma as a required metabolic sensor and transcriptional regulator of repair macrophages and establishes GDF3 as a secreted extrinsic effector protein acting on myoblasts and serving as an exclusively macrophage-derived regeneration factor in tissue repair | 27836432 |
| 2011-01-01 10:54:00 | GDF3 has the ability to induce progression of CD24-inducible melanoma in mice. | 20950440 |
| 2010-01-21 00:00:00 | Mice transduced with GDF-3 displayed profound weight gain when fed with high fat diet. The phenotypes included greatly expanded adipose tissue mass, increased body adiposity, highly hypertrophic adipocytes, hepatic steatosis, and elevated plasma leptin. | 15358131 |
| Type | IDs |
|---|---|
| Synonymous | C78318, Gdf-3, Vgr-2, Vgr2, ecat9 |
| Gene |
UniProtKB-ID:
GDF3_MOUSE
UniprotKB:
Q07104
UniParc:
UPI00000233CB
EMBL:
L06443,
AK152457,
AK160533,
S52658
Ensembl:
ENSMUSG00000030117
KO:
mmu:14562
|
| Nucleutide sequences |
EMBL-CDS:
BAE31235.1,
AAA53034.1,
BAE35850.1,
AAB24876.1
Ensembl_TRS:
ENSMUST00000032211
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000032211
RefSeq:
NP_032134.2,
XP_006505603.1
|
| Others |
UniRef100:
UniRef100_Q07104
UniRef90:
UniRef90_Q07104
UniRef50:
UniRef50_Q9NR23
UniGene:
Mm.299742
CCDS:
CCDS20499.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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