| Type | Description |
|---|---|
| Definition | GTP cyclohydrolase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 10:28:00 | CTRP13 preserves endothelial function in diabetic mice by regulating GCH1/BH4 axis-dependent eNOS coupling, suggesting the therapeutic potential of CTRP13 against diabetic vasculopathy. | 31676569 |
| 2020-05-23 12:40:00 | GCH1 knockout reduced, and its overexpression increased the tetrahydrobiopterin-mediated itching in mice. | 30450838 |
| 2019-12-07 10:24:00 | The GTPCH p.Leu117Arg missense mutation is deleterious and could cause tetrahydrobiopterin, phenylalanine and neurotransmitter metabolic disturbances and infancy-onset motor dysfunctions recessively. This is the first GTPCH deficiency mouse model which could be live-born and exhibits significant motor impairments. | 30742839 |
| 2019-08-17 11:14:00 | Suggest key roles for endothelial cell and leucocyte Gch1 and BH4 in the progression of atherosclerosis. | 29596571 |
| 2018-05-19 11:09:00 | GCH1-induced cardioprotection against DCM mainly involves the tetrahydrobiopterin/nNOS/sarcoplasmic reticulum Ca2+ handling proteins signaling pathway and depression of p38 Mitogen-Activated in Diabetes Mellitus, Type 1. | 27295516 |
| Type | IDs |
|---|---|
| Synonymous | GTP-CH, GTP-CH-I, GTPCH, Gch |
| Gene |
UniProtKB-ID:
GCH1_MOUSE,
Q3U7P6_MOUSE
UniprotKB:
Q05915,
Q3U7P6
UniParc:
UPI0000001891
EMBL:
S71373,
AK152571,
BC069921,
L09737,
BC005643
Ensembl:
ENSMUSG00000037580
KO:
mmu:14528
|
| Nucleutide sequences |
EMBL-CDS:
AAH05643.1,
AAH69921.1,
AAC60677.2,
AAA37757.1,
BAE31323.1
Ensembl_TRS:
ENSMUST00000089959
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000087405
RefSeq:
NP_032128.1
|
| Others |
UniRef100:
UniRef100_Q05915
UniRef90:
UniRef90_Q05915
UniRef50:
UniRef50_Q05915
UniGene:
Mm.10651
CCDS:
CCDS26984.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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