| Type | Description |
|---|---|
| Definition | glucagon receptor |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 11:06:00 | Both glucagon-receptor signaling and insulin-receptor signaling mutually contribute to blood glucose homeostasis and amino acid metabolism in mice. Glucagon receptor antagonism increased amino acids, lowered glycemia, and increased glucagon but did not influence insulin concentrations. | 30807215 |
| 2019-02-23 11:41:00 | Apart from their hyperaminoacidemia, Gcgr(-/-) mice display hyperglucagonemia, increased pancreatic content of glucagon and somatostatin (but not insulin), and alpha-cell hyperplasia and hypertrophy compared with WT littermates. | 28978545 |
| 2018-09-08 10:46:00 | Data, including data from studies using knockout mice, suggest that control of whole-body energy expenditure by Gcgr agonism requires intact Fxr signaling and Fgf21 secretion in liver. (Gcgr = glucagon receptor glucagon; Fxr = farnesoid X receptor; Fgf21 = fibroblast growth factor-21) | 29925501 |
| 2018-04-21 11:23:00 | we show that glucagon receptor (GCGR) inhibition with a monoclonal antibody normalized blood glucose and beta-hydroxybutyrate levels. Insulin receptor antagonism increased pancreatic beta-cell mass threefold. Normalization of blood glucose levels with GCGR-blocking antibody unexpectedly doubled beta-cell mass relative to that observed with S961 alone and 5.8-fold over control | 28115707 |
| 2018-03-10 11:36:00 | These results show that Slc38a5 is a key component of the feedback circuit between glucagon receptor signaling in the liver and amino-acid-dependent regulation of pancreatic alpha cell mass in mice. | 28591637 |
| Type | IDs |
|---|---|
| Synonymous | GR |
| Gene |
UniProtKB-ID:
GLR_MOUSE,
Q3UN81_MOUSE
UniprotKB:
Q61606,
Q3UN81
UniParc:
UPI00005AC2E7,
UPI0000022538
EMBL:
AK144393,
BC031885,
L38613,
S69384,
AL669855,
CH466558,
BC057988
Ensembl:
ENSMUSG00000025127
KO:
mmu:14527
|
| Nucleutide sequences |
EMBL-CDS:
AAH57988.1,
AAB30529.2,
AAH31885.1,
AAA88244.1,
EDL34761.1,
BAE25866.1
Ensembl_TRS:
ENSMUST00000026119
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026119
RefSeq:
XP_017169754.1,
XP_006532279.1,
XP_017169758.1,
XP_017169756.1,
XP_030101427.1,
NP_032127.2,
XP_006532280.1,
XP_017169757.1,
XP_017169755.1,
XP_017169752.1,
XP_036012228.1
|
| Others |
UniRef100:
UniRef100_Q3UN81,
UniRef100_Q61606
UniRef90:
UniRef90_Q61606
UniRef50:
UniRef50_Q61606
UniGene:
Mm.22329
CCDS:
CCDS25739.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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