| Type | Description |
|---|---|
| Definition | glucosidase, beta, acid |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:30:00 | Systemic enzyme delivery by blood-brain barrier-penetrating SapC-DOPS nanovesicles for treatment of neuronopathic Gaucher disease. | 32279952 |
| 2020-07-11 10:52:00 | Reduced GCase activity does not result in aggregation of alpha-synuclein. However, in the context of extant misfolded alpha-synuclein, GCase activity modulates neuronal susceptibility to pathology. Furthermore, this modulation does not depend on neuron type but rather is driven by the level of pathological alpha-synuclein seeds. | 31899072 |
| 2020-05-16 10:09:00 | Cognitive impairment was measured by two independent behavioural tests in heterozygous GBA1 mutant mice (D409V/WT). Reduced GBA1 GCase enzyme activity dis-equilibrates the finely balanced glycosphingolipid metabolism pathway. | 31299418 |
| 2020-03-14 12:32:00 | In Gba(L444P/WT) knockin mice, the L444P heterozygous Gba mutation triggers mitochondrial dysfunction by inhibiting autophagy and mitochondrial priming, two steps critical for the selective removal of dysfunctional mitochondria by autophagy, a process known as mitophagy. | 30160596 |
| 2020-03-14 12:21:00 | Delivery of Glucosylceramidase Beta Gene Using AAV9 Vector Therapy as a Treatment Strategy in Mouse Models of Gaucher Disease. | 30122074 |
| Type | IDs |
|---|---|
| Synonymous | GBA1, GC, GCase, GLUC, betaGC |
| Gene |
UniProtKB-ID:
GLCM_MOUSE,
A0A0G2JDK2_MOUSE
UniprotKB:
P17439,
A0A0G2JDK2
UniParc:
UPI0000F4DD7A,
UPI0000001475
EMBL:
AK082767,
AY115108,
BC006663,
M24119,
M89949,
AC161600
Ensembl:
ENSMUSG00000028048
KO:
mmu:14466
|
| Nucleutide sequences |
EMBL-CDS:
AAA37665.1,
AAH06663.1,
BAC38609.1,
AAM66757.1,
AAA37671.1
Ensembl_TRS:
ENSMUST00000167998,
ENSMUST00000077367,
ENSMUST00000197738
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000076589,
ENSMUSP00000130660,
ENSMUSP00000142401
RefSeq:
NP_032120.1,
NP_001070879.1
|
| Others |
UniRef100:
UniRef100_P17439,
UniRef100_A0A0G2JDK2
UniRef90:
UniRef90_P17439,
UniRef90_A0A0G2JDK2
UniRef50:
UniRef50_A0A663EN97,
UniRef50_P17439
UniGene:
Mm.5031
CCDS:
CCDS17493.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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