| Type | Description |
|---|---|
| Definition | alpha-2-macroglobulin like 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 11:32:00 | Study identified 16 novel A2ML1 variants in otitis media patients, two of which are pathogenic further providing evidence to support a role for A2ML1 in middle ear mucosal pathology. Sequencing of patients salivary RNA samples demonstrated lower A2ML1 expression according to the carriage of A2ML1 variants. | 31009165 |
| 2018-12-22 11:21:00 | The functional assessment supported the pathogenicity of the RAF1 and RIT1 variants of unknown significance (VUSs), while the significance of two VUSs in A2ML1 remained unclear. | 29402968 |
| 2017-12-30 10:41:00 | Brain gene expression of ZNF385A, PSD2, and A2ML1 and DNA methylation dysregulations are implicated in the alteration of brain tissue properties associated with late-life cognitive decline above and beyond the influence of common neuropathologic conditions. | 29084334 |
| 2017-07-22 13:09:00 | The indigenous Filipino population has a ~50% prevalence of otitis media. A2ML1 genotype is the primary risk factor for otitis media and main determinant of disease progression, although age, the middle ear microbiome, and social clusters might modulate the effect of the A2ML1 genotype. | 27484237 |
| 2017-02-18 12:11:00 | A2ML1-related otitis media susceptibility may be mediated by changes in the middle ear microbiome. | 27799062 |
| Type | IDs |
|---|---|
| Synonymous | CPAMD9, OMS, p170 |
| Gene |
UniProtKB-ID:
A2ML1_HUMAN,
B3KVV6_HUMAN
UniprotKB:
A8K2U0,
B3KVV6
UniParc:
UPI00004A23E7,
UPI000204AA86,
UPI000022904E
EMBL:
CH471116,
BC093840,
AK096448,
AK123601,
AC006513,
AK057908,
AL832139,
AK123591,
AK302555,
AK123592,
BC112131,
AC006581,
AK290355
Ensembl:
ENSG00000166535
KO:
hsa:144568
|
| Nucleutide sequences |
EMBL-CDS:
EAW88606.1,
BAH13740.1,
BAC85654.1,
AAH93840.2,
BAB71612.1,
BAF83044.1,
EAW88603.1,
BAC04793.1,
AAI12132.1,
BAC85653.1,
BAG53918.1
Ensembl_TRS:
ENST00000539547,
ENST00000299698
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000438292,
ENSP00000299698
RefSeq:
XP_011518868.1,
XP_016874358.1,
NP_653271.3,
XP_016874357.1,
XP_011518869.1,
NP_001269353.2,
XP_016874359.1
|
| Others |
UniRef100:
UniRef100_A8K2U0,
UniRef100_B3KVV6
UniRef90:
UniRef90_A8K2U0
UniRef50:
UniRef50_A8K2U0
UniGene:
Hs.620532
CCDS:
CCDS8596.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员