A reference map of the human binary protein interactome.

Nature     Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat Taşan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood

Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.

J Biol Chem     Brianna E Talbot , David H Vandorpe , Brian R Stotter , Seth L Alper , Johannes S Schlondorff

Architecture of the human interactome defines protein communities and disease networks.

Nature     Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.

Brief. Bioinformatics     Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas

A KCR1 variant implicated in susceptibility to the long QT syndrome.

J. Mol. Cell. Cardiol.     Kenshi Hayashi , Noboru Fujino , Hidekazu Ino , Katsuharu Uchiyama , Kenji Sakata , Tetsuo Konno , Eiichi Masuta , Akira Funada , Yuichiro Sakamoto , Toshinari Tsubokawa , Akihiko Hodatsu , Toshihiko Yasuda , Honin Kanaya , Min Young Kim , Sabina Kupershmidt , Haruhiro Higashida , Masakazu Yamagishi

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.

Nat. Genet.     Ann K Daly , Peter T Donaldson , Pallav Bhatnagar , Yufeng Shen , Itsik Pe'er , Aris Floratos , Mark J Daly , David B Goldstein , Sally John , Matthew R Nelson , Julia Graham , B Kevin Park , John F Dillon , William Bernal , Heather J Cordell , Munir Pirmohamed , Guruprasad P Aithal , Christopher P Day , DILIGEN Study , International SAE Consortium

Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

Genome Res.     Kouichi Kimura , Ai Wakamatsu , Yutaka Suzuki , Toshio Ota , Tetsuo Nishikawa , Riu Yamashita , Jun-ichi Yamamoto , Mitsuo Sekine , Katsuki Tsuritani , Hiroyuki Wakaguri , Shizuko Ishii , Tomoyasu Sugiyama , Kaoru Saito , Yuko Isono , Ryotaro Irie , Norihiro Kushida , Takahiro Yoneyama , Rie Otsuka , Katsuhiro Kanda , Takahide Yokoi , Hiroshi Kondo , Masako Wagatsuma , Katsuji Murakawa , Shinichi Ishida , Tadashi Ishibashi , Asako Takahashi-Fujii , Tomoo Tanase , Keiichi Nagai , Hisashi Kikuchi , Kenta Nakai , Takao Isogai , Sumio Sugano

In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.

Proc. Natl. Acad. Sci. U.S.A.     Christina I Petersen , Toni R McFarland , Svetlana Z Stepanovic , Ping Yang , David J Reiner , Kenshi Hayashi , Alfred L George , Dan M Roden , James H Thomas , Jeffrey R Balser

Complete sequencing and characterization of 21,243 full-length human cDNAs.

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The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.

FASEB J.     Sabina Kupershmidt , Iris C-H Yang , Kenshi Hayashi , Jian Wei , Siprachanh Chanthaphaychith , Christina I Petersen , Daivid C Johns , Alfred L George , Dan M Roden , Jeffrey R Balser