| Type | Description |
|---|---|
| Definition | prickle planar cell polarity protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 11:22:00 | Authors used a proteomic approach to identify protein complexes associated with PRICKLE1. The mRNA expression levels of the corresponding genes were assessed in 8982 patients with invasive primary breast cancer. AUthors then characterised the molecular interaction between PRICKLE1 and the guanine nucleotide exchange factor ECT2. | 30971775 |
| 2020-01-04 12:20:00 | showed that the patient's father (p.Asp760del) and mother (p.Asp201Asn) each had a mutation in prickle1 | 30564977 |
| 2019-11-02 11:05:00 | This clinical report highlights the fact that in the context of an epileptic encephalopathy with developmental arrest, early onset severe PME-ataxia syndrome can be a PRICKLE1-associated phenotype | 30345727 |
| 2017-08-05 12:56:00 | Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions. | 27378169 |
| 2017-06-24 11:39:00 | upregulation of PRICKLE1 in basal breast cancers, a subtype characterized by high metastatic potential, is associated with poor metastasis-free survival. | 27184734 |
| Type | IDs |
|---|---|
| Synonymous | EPM1B, RILP |
| Gene |
UniProtKB-ID:
PRIC1_HUMAN,
B3KVG3_HUMAN,
B3KVG6_HUMAN,
A0A024R0W7_HUMAN
UniprotKB:
Q96MT3,
B3KVG3,
B3KVG6,
A0A024R0W7
UniParc:
UPI00005A7AAF,
UPI000013D6F5,
UPI0000D47584
EMBL:
BC114939,
AK056189,
AK122881,
CH471111,
BC114940,
AK056499,
AF399844,
AK122877
Ensembl:
ENSG00000139174
KO:
hsa:144165
|
| Nucleutide sequences |
EMBL-CDS:
AAI14941.1,
AAQ03035.1,
AAI14940.1,
BAB71116.1,
BAB71198.1,
BAG53775.1,
BAG53778.1,
EAW57854.1,
EAW57855.1
Gene_ORFName:
hCG_39446
Ensembl_TRS:
ENST00000445766,
ENST00000455697,
ENST00000639958,
ENST00000639589,
ENST00000640132,
ENST00000345127,
ENST00000640055,
ENST00000548696,
ENST00000552240,
ENST00000639566
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000491228,
ENSP00000492332,
ENSP00000401060,
ENSP00000492763,
ENSP00000492644,
ENSP00000345064,
ENSP00000449819,
ENSP00000398947,
ENSP00000491051,
ENSP00000448359
RefSeq:
XP_011536249.1,
XP_016874328.1,
NP_694571.2,
XP_016874329.1,
NP_001138354.1,
NP_001138355.1,
NP_001138353.1,
XP_011536248.1,
XP_016874327.1
|
| Others |
UniRef100:
UniRef100_B3KVG6,
UniRef100_B3KVG3,
UniRef100_Q96MT3
UniRef90:
UniRef90_Q96MT3
UniRef50:
UniRef50_Q96MT3
UniGene:
Hs.524348,
Hs.720221
CCDS:
CCDS8742.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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