| Type | Description |
|---|---|
| Definition | gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:01:00 | Phosphorylation on Ser-359 of the alpha2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses. | 32620552 |
| 2020-04-11 10:47:00 | here we demonstrate that direction selectivity in downstream ganglion cells remains remarkably unaffected when starburst dendrites are rendered non-directional, using a novel strategy combining a conditional GABAA alpha2 receptor knockout mouse with optogenetics | 30714905 |
| 2018-12-29 12:15:00 | Gabra2-1 mice display spontaneous seizures during development, accompanied by early mortality | 30087324 |
| 2017-12-16 11:38:00 | At a lower concentration of fluoxetine and its active metabolite norfluoxetine (that is in the therapeutic range), study observed anxiogenic- and depressive-like actions in alpha2 knock-out mice, but not in alpha2+/+ mice, suggesting that in 129x1/SvJ mice a decrease in alpha2-containing GABAARs promotes an increased sensitivity to the prodepressant-like effects of chronic fluoxetine treatment. | 28587819 |
| 2017-08-12 12:07:00 | Findings suggest that ovarian cycle-related progesterone and neurosteroids regulate alpha2-GABA-A receptor expression in the hippocampus via a non-progesterone receptor pathway, which may be relevant to menstrual-cycle related brain conditions. | 28137424 |
| Type | IDs |
|---|---|
| Synonymous | C630048P16Rik, Gabra-2 |
| Gene |
UniProtKB-ID:
GBRA2_MOUSE,
Q544G1_MOUSE
UniprotKB:
P26048,
Q544G1
UniParc:
UPI0000004015
EMBL:
M86567,
AK039055,
BC115727
Ensembl:
ENSMUSG00000000560
KO:
mmu:14395
|
| Nucleutide sequences |
EMBL-CDS:
AAA37650.1,
BAC30223.1,
AAI15728.1
Ensembl_TRS:
ENSMUST00000197284
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000142892
RefSeq:
NP_032092.1,
XP_006503796.1
|
| Others |
UniRef100:
UniRef100_P26048
UniRef90:
UniRef90_P26048
UniRef50:
UniRef50_P14867
UniGene:
Mm.5304
CCDS:
CCDS19327.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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