| Type | Description |
|---|---|
| Definition | fragile X mental retardation gene 1, autosomal homolog |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:50:00 | FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. | 32328638 |
| 2019-12-14 12:03:00 | Here, we will review the unexpected roles of FXRalpha on the male reproductive tract. FXRa has been demonstrated to play functions in the regulation of testicular and prostate homeostasis. Even though additional studies are needed to confirm these findings in humans, the reviewed reports open new field of research to better define the effects of bile acid-FXRa signaling pathways on fertility disorders and cancers | 31407019 |
| 2019-09-21 11:14:00 | FXR deficiency increased hepatic steatosis and altered bile acid pool composition, contributing to worsened liver toxicity. | 30803859 |
| 2019-05-11 10:05:00 | GUDCA was further identified as an intestinal FXR antagonist that improved various metabolic endpoints in mice with established obesity. Thus, we conclude that metformin acts in part through a B. fragilis-GUDCA-intestinal FXR axis to improve metabolic dysfunction, including hyperglycemia | 30397356 |
| 2019-04-20 12:22:00 | FXR deficiency in hepatocytes might only play a minor role in alcoholic liver diseases (ALD) development. Deficiency of FXR in other non-hepatic tissues and/or increased bile acid levels resultant from whole-body FXR deficiency might be responsible for more severe ALD development. | 29730159 |
| Type | IDs |
|---|---|
| Synonymous | 1110050J02Rik, 9530073J07Rik, AI851072, Fxr1h, Fxr1p |
| Gene |
UniProtKB-ID:
FXR1_MOUSE,
A0A0G2JEP0_MOUSE
UniprotKB:
Q61584,
A0A0G2JEP0
UniParc:
UPI0000026FC1,
UPI00000289FB,
UPI000016C8A8,
UPI000002AA10,
UPI000002AA13,
UPI000002AA14,
UPI000002AA11,
UPI000002AA12
EMBL:
BC019139,
AF124386,
AF124391,
AC115078,
AF124393,
AF124394,
AF124385,
AF124388,
X90875,
AF124389,
AF124387,
AF124390,
AC068294,
AF124392
Ensembl:
ENSMUSG00000027680
KO:
mmu:14359
|
| Nucleutide sequences |
EMBL-CDS:
AAD30214.1,
AAD30215.1,
AAD30213.1,
AAD30217.1,
CAA62383.1,
AAH19139.1,
AAD30218.1,
AAD30211.1,
AAD30216.1,
AAD30212.1
Ensembl_TRS:
ENSMUST00000197694,
ENSMUST00000200392,
ENSMUST00000001620,
ENSMUST00000198051
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000142441,
ENSMUSP00000143392,
ENSMUSP00000001620,
ENSMUSP00000142847
RefSeq:
XP_036018790.1,
NP_001106660.1,
XP_006535465.1,
XP_036018789.1,
XP_006535463.1,
XP_036018788.1,
NP_001106659.1,
XP_006535464.1,
NP_032079.1
|
| Others |
UniRef100:
UniRef100_Q61584-3,
UniRef100_Q61584
UniRef90:
UniRef90_P51114
UniRef50:
UniRef50_P51114
UniGene:
Mm.259021
CCDS:
CCDS50891.1,
CCDS79896.1,
CCDS50890.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员