| Type | Description |
|---|---|
| Definition | mindbomb E3 ubiquitin protein ligase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 12:43:00 | Results suggest that MIB2 enhances NF-kappaB signaling in inflammation by promoting the ubiquitin-dependent degradation of CYLD. | 31366726 |
| 2019-09-21 11:36:00 | MIB2 represses the cytotoxic potential of RIPK1 by ubiquitylating lysine residues in the C-terminal portion of RIPK1. Disruption of MIB2-mediated ubiquitylation, either by mutation of MIB2's E3 activity or RIPK1's ubiquitin-acceptor lysines, sensitizes cells to RIPK1-mediated cell death. | 29642005 |
| 2017-09-30 13:41:00 | Missense p.V742G variant in MIB2 is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy. | 28013292 |
| 2015-10-03 10:23:00 | Here, we report a novel interaction between CYLD and MIB2 that supports the hypothesis that the CYLD/MIB2 interaction might play a pathogenic role in human cancer. | 25565632 |
| 2015-02-21 10:46:00 | The DLAIS motif in MAVS was found to be critical for MIB2 binding, the ligation of K63-linked ubiquitin to TANK-binding kinase 1, and phosphorylation-mediated IRF3/7 activation. | 25142606 |
| Type | IDs |
|---|---|
| Synonymous | ZZANK1, ZZZ5 |
| Gene |
UniProtKB-ID:
MIB2_HUMAN
UniprotKB:
Q96AX9
UniParc:
UPI000066D8B3,
UPI0001C0B379,
UPI000006DCEE,
UPI00015E0B0C,
UPI00015E0B0A,
UPI00004A2928,
UPI0001C0B37B,
UPI000007199C,
UPI0001C0B378,
UPI00015E0B0B,
UPI00018132AE,
UPI0001C0B37A,
UPI00018132AD,
UPI00018132AF
EMBL:
BC016490,
AK091610,
AK128167,
AK302757,
AK097106,
AL834527,
AB076691,
AK098785,
AB076692,
AL691432,
BC037542,
AK096295,
AK095914,
AK122863,
AB064367,
AB074480,
AK122751,
AB076693,
AB097000
Ensembl:
ENSG00000197530
KO:
hsa:142678
|
| Nucleutide sequences |
EMBL-CDS:
BAC00994.1,
BAC05413.1,
BAC04952.1,
BAC00992.1,
BAG63969.1,
BAC00993.1,
BAC03707.1,
AAH16490.1,
BAB82979.1,
BAC04646.1,
BAC77353.1,
BAG53705.1,
BAB92950.1,
BAG53766.1,
CAD39183.1,
AAH37542.1,
BAG54643.1,
BAC04752.1
Ensembl_TRS:
ENST00000355826,
ENST00000378712,
ENST00000505820,
ENST00000520777,
ENST00000518681
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000367984,
ENSP00000428264,
ENSP00000428660,
ENSP00000348081,
ENSP00000426103
RefSeq:
XP_006710435.1,
NP_001164160.1,
XP_016855853.1,
XP_016855839.1,
NP_001164159.2,
XP_016855843.1,
NP_543151.4,
NP_001164157.3,
XP_011539038.1,
XP_016855851.1,
XP_016855850.1,
XP_016855841.1,
XP_011539044.1,
XP_024309086.1,
XP_024309087.1,
XP_016855848.1,
XP_011539043.1,
XP_016855840.1,
XP_024309085.1,
XP_016855847.1,
XP_016855855.1,
XP_016855852.1,
XP_016855842.1,
XP_016855838.1,
NP_001164158.3,
XP_016855846.1,
XP_016855844.1,
XP_016855845.1,
XP_016855854.1,
XP_011539039.1,
XP_016855849.1,
XP_011539033.1
|
| Others |
UniRef100:
UniRef100_Q96AX9
UniRef90:
UniRef90_Q96AX9
UniRef50:
UniRef50_Q96AX9
UniGene:
Hs.135805,
Hs.593430
CCDS:
CCDS53262.1,
CCDS41224.2,
CCDS53261.1,
CCDS53263.1,
CCDS53264.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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