| Type | Description |
|---|---|
| Definition | crystallin gamma D |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:47:00 | Cataract-Associated New Mutants S175G/H181Q of betaBeta2-Crystallin and P24S/S31G of gammaD-Crystallin Are Involved in Protein Aggregation by Structural Changes. | 32899552 |
| 2020-09-19 16:25:00 | Temperature-Dependent Interactions Explain Normal and Inverted Solubility in a gammaD-Crystallin Mutant. | 31422822 |
| 2020-09-12 15:58:00 | Kinetic Stability of Long-Lived Human Lens gamma-Crystallins and Their Isolated Double Greek Key Domains. | 31266635 |
| 2020-06-13 11:45:00 | The W42R variant assumes a distinct conformation in solution that leaves the Greek key domains of the native fold largely unaltered but lacks the hydrophobic interdomain interface that is key to the stability of wild-type gammaD-crystallin. | 31393108 |
| 2019-04-13 10:57:00 | a previously unknown oxidoreductase activity in gammaD-crystallin (HgammaD) is found. This activity was assigned to a redox-active internal disulfide bond that is dynamically exchanged among HgammaD molecules. The W42Q variant acts as a disulfide sink, reducing oxidized WT and forming a distinct internal disulfide that kinetically traps the aggregation-prone intermediate. | 30242128 |
| Type | IDs |
|---|---|
| Synonymous | CACA, CCA3, CCP, CRYG4, CTRCT4, PCC, cry-g-D |
| Gene |
UniProtKB-ID:
CRGD_HUMAN,
A0A140CTX7_HUMAN
UniprotKB:
P07320,
A0A140CTX7
UniParc:
UPI0000161BE3
EMBL:
U66583,
AC093698,
K03006,
CH471063,
BC117338,
KT966392,
BC117340,
K03005
Ensembl:
ENSG00000118231,
ENSG00000285434
KO:
hsa:1421
|
| Nucleutide sequences |
EMBL-CDS:
AAY24041.1,
AAB38686.1,
AAI17341.1,
AAA52112.1,
AAI17339.1,
AMH87785.1,
EAW70432.1
Gene_ORFName:
hCG_15938
Ensembl_TRS:
ENST00000264376,
ENST00000644920
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000496652,
ENSP00000264376
RefSeq:
NP_008822.2
|
| Others |
UniRef100:
UniRef100_P07320
UniRef90:
UniRef90_P07320
UniRef50:
UniRef50_P07320
UniGene:
Hs.546247
CCDS:
CCDS2378.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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