| Type | Description |
|---|---|
| Definition | fumarate hydratase 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-08-19 12:38:00 | roles for fumarate metabolism in hematopoietic stem cell (HSC) maintenance and hematopoietic differentiation and reveal a differential requirement for mitochondrial Fh1 in normal hematopoiesis and leukemia propagation. | 28202494 |
| 2017-06-03 12:20:00 | Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance. | 27554470 |
| 2013-12-21 10:34:00 | Reexpression of cytosolic FH in FH1-deficient mice is critical for the suppression of renal cyst development and restoration of defects in the arginine biosynthesis pathway. | 23643539 |
| 2012-10-13 10:14:00 | study found that loss of FH activity conferred protection from apoptosis in normal human renal cells and fibroblasts | 22645311 |
| 2012-09-01 11:06:00 | Tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation. | 22677546 |
| Type | IDs |
|---|---|
| Synonymous | Fh, Fh-1 |
| Gene |
UniProtKB-ID:
FUMH_MOUSE
UniprotKB:
P97807
UniParc:
UPI00001EDFE7,
UPI0000022924
EMBL:
AK002379,
AK147000,
U72679,
BC006048,
CH466555
Ensembl:
ENSMUSG00000026526
KO:
mmu:14194
|
| Nucleutide sequences |
EMBL-CDS:
EDL13210.1,
BAE27597.1,
AAB51039.1,
AAH06048.1
Ensembl_TRS:
ENSMUST00000027810
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027810
RefSeq:
NP_034339.2
|
| Others |
UniRef100:
UniRef100_P97807
UniRef90:
UniRef90_P97807
UniRef50:
UniRef50_P97807
UniGene:
Mm.41502
CCDS:
CCDS15547.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员