| Type | Description |
|---|---|
| Definition | leucine rich repeat containing G protein coupled receptor 5 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-28 19:07:00 | Interleukin-10 expands transit-amplifying cells while depleting Lgr5(+) stem cells via inhibition of Wnt and notch signaling. | 33066957 |
| 2020-11-21 13:14:00 | Loss of Apc Rapidly Impairs Programs and Cell Fate Decisions in Lgr5(+) Intestinal Stem Cells. | 32213541 |
| 2020-09-05 13:53:00 | The vanillin derivative VND3207 protects intestine against radiation injury by modulating p53/NOXA signaling pathway and restoring the balance of gut microbiota. | 31580946 |
| 2020-08-15 19:05:00 | PP2A Deficiency Enhances Carcinogenesis of Lgr5(+) Intestinal Stem Cells Both in Organoids and In Vivo. | 31905853 |
| 2020-08-01 12:09:00 | Mouse liver tumors contain the enrichment of LGR5 expressing cells. Isolated LGR5 expressing cells from mouse liver tumors are superior in initiating organoids and forming tumors upon engraftment, featuring candidate tumor-initiating cells. These cells are resistant to conventional treatment including sorafenib and 5-FU. LGR5 lineage ablation inhibits organoid initiation and tumor growth. | 32327656 |
| Type | IDs |
|---|---|
| Synonymous | FEX, Gpr49 |
| Gene |
UniProtKB-ID:
LGR5_MOUSE
UniprotKB:
Q9Z1P4
UniParc:
UPI0000021838
EMBL:
CH466539,
AF110818,
AK132387
Ensembl:
ENSMUSG00000020140
KO:
mmu:14160
|
| Nucleutide sequences |
EMBL-CDS:
AAD14684.1,
BAE21138.1,
EDL21773.1
Ensembl_TRS:
ENSMUST00000020350
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000020350
RefSeq:
NP_034325.2
|
| Others |
UniRef100:
UniRef100_Q9Z1P4
UniRef90:
UniRef90_Q9Z1P4
UniRef50:
UniRef50_O75473
UniGene:
Mm.42103
CCDS:
CCDS24180.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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