| Type | Description |
|---|---|
| Definition | fibroblast activation protein |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:04:00 | d, these data suggest that Fap restrains the progression of atherosclerosis and may contribute to the sexually dimorphic susceptibility to atherosclerosis by regulating the balance between inflammation and fibrosis | 32084369 |
| 2020-06-13 10:04:00 | Embryonic FAP(+) lymphoid tissue organizer cells generate the reticular network of adult lymph nodes. | 31324739 |
| 2020-05-16 11:50:00 | Data demonstrated a novel role for fibroblast activation protein in regulating weight gain and adipocyte hypertrophy. FAP expression by pre-adipocytes provides a cell-intrinsic restriction on adipogenic differentiation, and FAP-mediated collagen remodeling alters lipid metabolism in mature adipocytes. Its loss impairs collagen accumulation, suggesting a novel link between matrix degradation and fibrillogenesis. | 31325484 |
| 2019-11-30 12:03:00 | Study identified many potential FAP substrates including ECM and immunoregulatory proteins, several of which were confirmed to have implications for the role of FAP in health and disease. | 30257879 |
| 2019-01-12 12:11:00 | The findings provide a novel regulation mechanism on FAPalpha expression and highlight the role of snail/FAPalpha axis as a novel target for melanoma treatment. | 29410133 |
| Type | IDs |
|---|---|
| Synonymous | SIMP |
| Gene |
UniProtKB-ID:
SEPR_MOUSE
UniprotKB:
P97321
UniParc:
UPI000002B369,
UPI0000028CD5,
UPI000002B368
EMBL:
Y10007,
BC019190
Ensembl:
ENSMUSG00000000392
KO:
mmu:14089
|
| Nucleutide sequences |
EMBL-CDS:
AAH19190.1,
CAA71116.1
Ensembl_TRS:
ENSMUST00000102732,
ENSMUST00000000402,
ENSMUST00000174448
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000134386,
ENSMUSP00000099793,
ENSMUSP00000000402
RefSeq:
NP_032012.1
|
| Others |
UniRef100:
UniRef100_P97321
UniRef90:
UniRef90_P97321
UniRef50:
UniRef50_Q12884
UniGene:
Mm.41816
CCDS:
CCDS16067.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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