| Type | Description |
|---|---|
| Definition | signal regulatory protein alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:33:00 | The CD47-SIRPalpha Immune Checkpoint. | 32433947 |
| 2020-09-26 13:07:00 | Signal regulatory protein alpha protects podocytes through promoting autophagic activity. | 30888336 |
| 2020-09-12 12:38:00 | The enzymatic activity of isoQC is required for the sufficient binding of SIRPalpha to CD47. | 31089204 |
| 2020-08-01 14:22:00 | Results show that SIRPalpha plays an important role as an anti-insulin mediator regulating pathways to cachexia. In muscle-specific SIRPalpha KO, changes in SIRPalpha serum levels seem to improve insulin signalling in muscle and white adipose tissue, suggesting crosstalk between muscle and adipose tissue. | 31507080 |
| 2020-07-11 10:22:00 | We also demonstrate the utility of the assay to characterize the activity of the first reported small molecule antagonists of the SIRPa-CD47 interaction. | 32240171 |
| Type | IDs |
|---|---|
| Synonymous | BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP |
| Gene |
UniProtKB-ID:
SHPS1_HUMAN
UniprotKB:
P78324
UniParc:
UPI0000071D10,
UPI0000073ADE,
UPI0001FDB815
EMBL:
BC033092,
BC038510,
BC026692,
AK290776,
AB023430,
Y10375,
D86043,
AL117335,
BC075849,
AK312521,
Y11047,
AL034562
Ensembl:
ENSG00000198053
KO:
hsa:140885
|
| Nucleutide sequences |
EMBL-CDS:
AAH26692.1,
BAG35420.1,
CAA71944.1,
AAH33092.1,
CAA71403.1,
BAA87929.1,
BAF83465.1,
AAH38510.1,
AAH75849.1,
BAA12974.1
Ensembl_TRS:
ENST00000358771,
ENST00000622179,
ENST00000400068,
ENST00000356025
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000478763,
ENSP00000382941,
ENSP00000351621,
ENSP00000348307
RefSeq:
NP_001035111.1,
XP_005260727.1,
NP_001035112.1,
NP_001317657.1,
NP_542970.1,
XP_006723608.1,
XP_024307604.1,
XP_011527475.1
|
| Others |
UniRef100:
UniRef100_P78324
UniRef90:
UniRef90_P78324
UniRef50:
UniRef50_P78324
UniGene:
Hs.581021
CCDS:
CCDS82593.1,
CCDS13022.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员