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14087 Fanca

14087

Fanca

Fanconi anemia, complementation group A

protein-coding

Mus musculus

基因描述

Type Description
Definition Fanconi anemia, complementation group A

研究结论

Date Results Publications
2021-02-06 13:59:00 A heterozygous hypomorphic mutation of Fanca causes impaired follicle development and subfertility in female mice. 33025164
2019-01-19 10:37:00 Using Fanca(-/-) HSCs expressing the separation-of-function mutant p53(515C) transgene, which selectively impairs the p53 function in apoptosis but keeps its cell-cycle checkpoint activities intact, we show that the p53 cell-cycle function is specifically required for the regulation of Fanca(-/-) HSC proliferation. 29307578
2018-05-12 12:09:00 Fanca(-/-) mice showed a skewed Vkappa gene usage. 27883081
2016-03-19 10:58:00 FANCA safeguards interphase and mitosis during hematopoiesis 26366677
2015-02-14 12:48:00 study indicates that Fanca expression during endomitosis is crucial for normal megakaryopoiesis and platelet production. 25261197

名称对应

Type IDs
Synonymous AW208693, FACA
Gene
UniProtKB-ID: FANCA_MOUSE
UniprotKB: Q9JL70
UniParc: UPI0000218D00
EMBL: AF208120, AF178934, AF247181, AF208117, AF230373, AF208122, AF208123, AC155810, AF208118, AF208121, AF208116
Ensembl: ENSMUSG00000032815
KO: mmu:14087
Nucleutide sequences
EMBL-CDS: AAF63963.1, AAF63964.1, AAF63966.1, AAG02637.1, AAF63969.1, AAF63967.1, AAG00417.1, AAF63965.1, AAG01633.1, AAF63968.1
Ensembl_TRS: ENSMUST00000035495
Protein sequencees
Ensembl_PRO: ENSMUSP00000045217
RefSeq: XP_006530727.1, XP_006530728.1, XP_006530725.1, XP_006530724.1, XP_036009646.1, XP_006530726.1, NP_058621.2
Others
UniRef100: UniRef100_Q9JL70
UniRef90: UniRef90_Q9JL70
UniRef50: UniRef50_Q9JL70
UniGene: Mm.6536, Mm.444516
CCDS: CCDS22753.1

全选

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